Protein Alignment Cyp313a4 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 139/531 - (26%)
• Similarity: 239/531 - (45%)
• Gaps: 101/531 - (19%)

  Fly     3 TWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAFG--------- 58
            ||.|....|.|.:||..:|...|  ..|.||||...|:.|         .|.| :|
  Rat    11 TWVLLATSLMLFYIYGTYSHGLF--KKLGIPGPKPVPLFG---------TIFN-YGDGMWKFDDD 63

  Fly    59 CFLDKHGPTIFSWLGPIPFMIVSDPQVVQ--------DIFTSPHCVN-KGIIYKAVDDGAGVGLF 114
            |: .|:|.....:.||.||:.:.||::::        .:||:..|.. .|.:.||:.
  Rat    64 CY-KKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAIT-------- 119

  Fly   115 SLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSFTL 175
            ..:|..|...|.:|:|.|....|....|:..:....||..|...:..||    ||   :..::::
  Rat   120 MSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEAKGEPINMKD---IFGAYSM 181

  Fly   176 GIATQTTMGSDV----KDEESF--RSNSLLGRYQCILETMTDMCFSPWLN--------SRFCRQL 226
            .:.|.|:.|.:|    ..::.|  ::..:| ::|.....:..:...|:|.        |.|.|
  Rat   182 DVITGTSFGVNVDSLNNPQDPFVQKAKKIL-KFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPR-- 243

  Fly   227 AGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNL--FLNLVTDLMR-RGVFTLKN 288
                    |:....::|::.:.:.:|           .||.|:.  ||.|:.:... :|..:.|.
  Rat   244 --------QSMNFFKKFVKTMKKNRL-----------DSNQKSRVDFLQLMMNTQNSKGQESQKA 289

  Fly   289 VED-----ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQ 348
            :.|     ::.|.:||.::.|:.::.:.:..||..|..|::...||....||..  .|:|....:
  Rat   290 LSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKA--PVTYDALME 352

  Fly   349 MVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFN 413
            |.|||:::|||:|:.|....:.|.:.:|::: ||:.:|||..:.|.||.:||:.:.| .:.|.||
  Rat   353 MEYLDMVVNESLRLYPIATRLDRVSKKDVEI-NGVFIPKGTVVTIPIYPLHRNPEYW-LEPEEFN 415

  Fly   414 PDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDI 478
            |:.|...|.....||.|:||..|.|||||.|:||||.|:.:..:|:|:..:   |.|.    ..|
  Rat   416 PERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQ---PCEK----TQI 473

  Fly   479 TMKLKSVPLLE 489
            .:|:...|:.:
  Rat   474 PLKISRQPIFQ 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	118/458 (26%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	119/462 (26%)