DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4a2

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	133/535 - (24%)
Similarity:	233/535 - (43%)	Gaps:	95/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLFLLWIYF----LWSRRRFYLLTL-KIPGPLGYPILGMAHWLMRR-------EDILNAFGCFLD 62
            ||.|..:.|    .:.||::.|..| |.|..       .:|||...       :.:|.    :::
  Rat    24 LLSLFLVLFKAVQFYLRRQWLLKALEKFPST-------PSHWLWGHNLKDREFQQVLT----WVE 77

  Fly    63 KHGPTIFSWL-GPIPFMIVSDPQVVQDIF--TSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIH 124
            |.......|| |....:::.||..|:.:.  :.|.      .|:::....|.||..|...:|..|
  Rat    78 KFPGACLQWLSGSTARVLLYDPDYVKVVLGRSDPK------PYQSLAPWIGYGLLLLNGKKWFQH 136

  Fly   125 RKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQD-DGEKDLIPLLQSFTL------GIATQTT 182
            |::|.|||.:.:|..::.|.....:::||:.|.|.| |...::...:...||      ..:.|.:
  Rat   137 RRMLTPAFHYDILKPYVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGS 201

  Fly   183 MGSDVKD------------------EESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGK 229
            :..||..                  ..:|..||::          .:|.....|:.|.| |:|.:
  Rat   202 VQLDVNSRSYTKAVEDLNNLIFFRVRSAFYGNSII----------YNMSSDGRLSRRAC-QIAHE 255

  Fly   230 ES---HYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVED 291
            .:   ....|...:...:.|..:.:|..:|     .:|...|...|:.:..|:...:...|::.|
  Rat   256 HTGSVFLLPAFLSLSDGVIKTRKAQLQNEE-----ELQKARKKRHLDFLDILLFAKMEDGKSLSD 315

  Fly   292 ES-----NIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMV 350
            |.     :..:|...:|||:.:.:....||..||:|||..||:::|.   || ..|::....||.
  Rat   316 EDLRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEVQSIL---GDGTSVTWDHLDQMP 377

  Fly   351 YLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPD 415
            |..:.:.|::|:..|||.|||:.|..:...:|..:|||:::.|.||.:|.:...| |:.:.|:|.
  Rat   378 YTTMCIKEALRLYSPVPSVSRELSSPVTFPDGRSIPKGIRVTILIYGLHHNPSYW-PNPKVFDPS 441

  Fly   416 HFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF---KTSFPFENLYFVED 477
            .|.|.:  .:|.:||:||:.|.|||||.::|:...||.:|..|..:..   .|..|..    :..
  Rat   442 RFSPDS--PRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVP----MPR 500

  Fly   478 ITMKLKSVPLLELQK 492
            :.:|.|:...|.|:|
  Rat   501 LVLKSKNGIHLRLKK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	117/478 (24%)
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	117/478 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810