Protein Alignment Cyp313a4 and CYP19A1

DIOPT Version :9

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 126/515 - (24%)
• Similarity: 203/515 - (39%)
• Gaps: 105/515 - (20%)

  Fly     6 LWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGY-----PIL--GMAHWLMRREDILNAFGCFLDK 63
            |..||..|:|         .|..|..|||| ||     |::  |...|:    .|.:|...:...
Human    30 LLTGLFLLVW---------NYEGTSSIPGP-GYCMGIGPLISHGRFLWM----GIGSACNYYNRV 80

  Fly    64 HGPTIFSWLGPIPFMIVSDPQVVQDIFTSPH------------CV---NKGIIYKAVDDGAGVGL 113
            :|..:..|:.....:|:|....:..|....|            |:   .||||:.
Human    81 YGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFN---------- 135

  Fly   114 FSLKDPR-WSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPL-QDDGEKDLIPLLQSFTLG 176
               .:|. |...|.....|.....|:..:.:........||:||.: .:.|..|::.||:...|.
Human   136 ---NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLD 197

  Fly   177 IATQTTMGSDVKDEES---FRSNSLLGRYQCILETMTDMCFS-PWLNSRFCRQLAGKESHYYQAK 237
              |..|:...:..:||   .:.......:|.:| ...|:.|. .||..::       |......|
Human   198 --TSNTLFLRIPLDESAIVVKIQGYFDAWQALL-IKPDIFFKISWLYKKY-------EKSVKDLK 252

  Fly   238 TEIRQFI----RKI-IERKLAEDEMGALPSIQSNDKNLFLNLVTDLM---RRGVFTLKNVEDESN 294
            ..|...|    |:| .|.||.|                .::..|:|:   :||..|.:||.....
Human   253 DAIEVLIAEKRRRISTEEKLEE----------------CMDFATELILAEKRGDLTRENVNQCIL 301

  Fly   295 IIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNES 359
            .::..|.:|.:.::::.|.|:|..|..:|...:||:|:.   |:.|:...|.|::..::..:.||
Human   302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI---GERDIKIDDIQKLKVMENFIYES 363

  Fly   360 MRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETF-NPDHFLPHNIQ 423
            ||..|.|.:|.|:..:| .:.:|..|.||..|.::|..|||        .|.| .|:.|...|..
Human   364 MRYQPVVDLVMRKALED-DVIDGYPVKKGTNIILNIGRMHR--------LEFFPKPNEFTLENFA 419

  Fly   424 DKHPYAYI-PFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKT--SFPFENLYFVEDITM 480
            ...||.|. ||..|.|.|.|...|::..|..|..|||.:..||  ....|::..:.|:::
Human   420 KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	114/469 (24%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	109/459 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5536
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860