Protein Alignment Cyp313a4 and CYP4B1

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 138/501 - (27%)
• Similarity: 214/501 - (42%)
• Gaps: 81/501 - (16%)

  Fly     6 LWC-GLL----FLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAFGCFLDKHG 65
            ||. ||:    ||..|:.|..|:.......|.|||       ..|||......:...|. |||
Human    15 LWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGP-------PTHWLFGHALEIQETGS-LDK-- 69

  Fly    66 PTIFSWLGPIP------------FMIVSDPQVVQDIFT--SPHCVNKGIIYKAVDDGAGVGLFSL 116
              :.||....|            |:.:.:|...:.:::  .|...:   :|.......|.||..|
Human    70 --VVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD---VYDFFLQWIGRGLLVL 129

  Fly   117 KDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK-DLIPLLQSFTLGIATQ 180
            :.|:|..|||||.|.|.:.||..::.:|...|.::||:.|....:|:. |:...:....|....:
Human   130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMK 194

  Fly   181 TTMGSDVKDEESFRSNSLLGR-----YQCILETMTDMC------------FSPWL---NSRFCRQ 225
            .|.|         |.::.||.     |...:..:|.:.            |..||   ..||.|.
Human   195 CTFG---------RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250

  Fly   226 LAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVE 290
            ......|..|.          |.|||.|..:......||:.....||:::..........|.:.:
Human   251 CQVAHDHTDQV----------IRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDAD 305

  Fly   291 --DESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFD-VSYADTQQMVYL 352
              .|.:..:|...:||.:.:.:.|..:|::||:|.|..||::.|.   ||.| ..:.|..:|.||
Human   306 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL---GDQDFFQWDDLGKMTYL 367

  Fly   353 DLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHF 417
            .:.:.||.|:.||||.|.||.|:.:...:|..:|.|..|::.||.:||:..:| ||.|.|:...|
Human   368 TMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW-PDPEVFDSLRF 431

  Fly   418 LPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF 463
            ...|...:||:|::||:.|.|||||.::|:...||..|..|..:.|
Human   432 STENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	118/437 (27%)
CYP4B1	NP_001093242.1	CYP4B-like	67..502	CDD:410771	121/441 (27%)