DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	501	Identity:	138/501 - (27%)
Similarity:	214/501 - (42%)	Gaps:	81/501 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LWC-GLL----FLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAFGCFLDKHG 65
            ||. ||:    ||..|:.|..|:.......|.|||       ..|||......:...|. |||
Human    15 LWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGP-------PTHWLFGHALEIQETGS-LDK-- 69

  Fly    66 PTIFSWLGPIP------------FMIVSDPQVVQDIFT--SPHCVNKGIIYKAVDDGAGVGLFSL 116
              :.||....|            |:.:.:|...:.:::  .|...:   :|.......|.||..|
Human    70 --VVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPD---VYDFFLQWIGRGLLVL 129

  Fly   117 KDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK-DLIPLLQSFTLGIATQ 180
            :.|:|..|||||.|.|.:.||..::.:|...|.::||:.|....:|:. |:...:....|....:
Human   130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMK 194

  Fly   181 TTMGSDVKDEESFRSNSLLGR-----YQCILETMTDMC------------FSPWL---NSRFCRQ 225
            .|.|         |.::.||.     |...:..:|.:.            |..||   ..||.|.
Human   195 CTFG---------RGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRA 250

  Fly   226 LAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVE 290
            ......|..|.          |.|||.|..:......||:.....||:::..........|.:.:
Human   251 CQVAHDHTDQV----------IRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDAD 305

  Fly   291 --DESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFD-VSYADTQQMVYL 352
              .|.:..:|...:||.:.:.:.|..:|::||:|.|..||::.|.   ||.| ..:.|..:|.||
Human   306 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREIL---GDQDFFQWDDLGKMTYL 367

  Fly   353 DLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHF 417
            .:.:.||.|:.||||.|.||.|:.:...:|..:|.|..|::.||.:||:..:| ||.|.|:...|
Human   368 TMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW-PDPEVFDSLRF 431

  Fly   418 LPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF 463
            ...|...:||:|::||:.|.|||||.::|:...||..|..|..:.|
Human   432 STENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEF 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	128/469 (27%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	128/469 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810