Protein Alignment Cyp313a4 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 136/525 - (25%)
• Similarity: 232/525 - (44%)
• Gaps: 84/525 - (16%)

  Fly     3 TWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILG------MAHWLMRREDILNAFGCFL 61
            ||.|....|.||::|  .:|.......|.||||...|:||      ...|....|       |:
Human    11 TWLLLAVSLVLLYLY--GTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTE-------CY- 65

  Fly    62 DKHGPTIFSWLGPIPFMIVSDPQVVQ--------DIFTSPHCVNK-GIIYKAVDDGAGVGLFSL- 116
            .|:|....::.|.:|.:.::||.|::        .:||:...:.. |.:..|:         ||
Human    66 KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAI---------SLA 121

  Fly   117 KDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSFTLGI 177
            :|..|...|.||:|.|....|....||..:...:|:..|....:.|:    ||   :..::::.:
Human   122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKD---IFGAYSMDV 183

  Fly   178 ATQTTMGSDV----KDEESF-RSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAK 237
            .|.|:.|.::    ..::.| .|.....::..:......:...|:|...|      :..:.....
Human   184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVF------EALNVSLFP 242

  Fly   238 TEIRQFIRKIIERKLAEDEMGALPSIQSNDKNL----FLNLVTDLMR-RGVFTLKNVED-----E 292
            .:...|:.|.:.|         :...:.|||..    ||.|:.|... :...:.|.:.|     :
Human   243 KDTINFLSKSVNR---------MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQ 298

  Fly   293 SNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILN 357
            |.|.:|..:|||::.:.:||..||..|:.|::..:||..:.||..  ..:|....||.|||:::|
Human   299 SIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKA--PPTYDAVVQMEYLDMVVN 361

  Fly   358 ESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNI 422
            |::|:.|....:.|...:|::: ||:.:|||..:.|..|.:|...|.| .:.|.|.|:.|....
Human   362 ETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYW-TEPEEFRPERFSKKK- 423

  Fly   423 QDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPL 487
            ....||.|.||..|.|||||.|:||::.|:.|.::|:|:.||   |.:.    ..|.:||.:..|
Human   424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFK---PCKE----TQIPLKLDTQGL 481

  Fly   488 LELQK 492
            |:.:|
Human   482 LQPEK 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	114/452 (25%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	117/459 (25%)