Protein Alignment Cyp313a4 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 144/543 - (26%)
• Similarity: 239/543 - (44%)
• Gaps: 115/543 - (21%)

  Fly     1 MLTWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILN---AFGCFLD 62
            |.||.|....|.||::|...|...|  ..|.||||...|.||         :||:   .| |..|
Human     9 METWLLLAVSLVLLYLYGTHSHGLF--KKLGIPGPTPLPFLG---------NILSYHKGF-CMFD 61

  Fly    63 -----KHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHC----VNK------GIIYKAVDDGAGVG 112
                 |:|.....:.|..|.:.::||.:::.:... .|    .|:      |.:..|:.
Human    62 MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK-ECYSVFTNRRPFGPVGFMKSAIS------ 119

  Fly   113 LFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSF 173
              ..:|..|...|.||:|.|....|...:||..:...:|:..|....:.|:    ||   :..::
Human   120 --IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD---VFGAY 179

  Fly   174 TLGIATQTTMGSDV----KDEESFRSNS-LLGRYQC----------------ILETMTDMCFSPW 217
            ::.:.|.|:.|.::    ..::.|..|: .|.|:..                |||.: ::|..|
Human   180 SMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL-NICVFP- 242

  Fly   218 LNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNL--FLNLVTDLMR 280
                                .|:..|:||.::| :.|..      ::...|:.  ||.|:.|...
Human   243 --------------------REVTNFLRKSVKR-MKESR------LEDTQKHRVDFLQLMIDSQN 280

  Fly   281 -RGVFTLKNVED-----ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDF 339
             :...:.|.:.|     :|.|.:|..:|||::.:.:.:..||..|:.|::..|||..:.||..
Human   281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA-- 343

  Fly   340 DVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKI 404
            ..:|....||.|||:::||::|:.|....:.|...:|::: ||:.:||||.:.|..|.:||..|.
Human   344 PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKY 407

  Fly   405 WGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPF 469
            | .:.|.|.|:.|...|..:..||.|.||..|.|||||.|:||::.|:.|.::|:|:.||   |.
Human   408 W-TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK---PC 468

  Fly   470 ENLYFVEDITMKLKSVPLLELQK 492
            :.    ..|.:||....||:.:|
Human   469 KE----TQIPLKLSLGGLLQPEK 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	118/466 (25%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	121/473 (26%)