DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	134/527 - (25%)
Similarity:	220/527 - (41%)	Gaps:	106/527 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLFL----LW-IYFLWSRRRFYLLTLKIPGPLGYPILG-MAHWLMRREDIL----NAFGCFLDKH 64
            ||||    || :|.:.||.|...|.|. ||.:|:|..| ....:::|...|    ..:|.....|
  Rat    19 LLFLAALKLWDLYCVSSRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTH 82

  Fly    65 ---GPTIFSW---------LGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLK 117
               .||:...         ||....:.|..|..|:.|.                 |||. |.:|.
  Rat    83 LFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL-----------------GAGC-LSNLH 129

  Fly   118 DPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLI--PLLQSFTLGIATQ 180
            |......:|::..||..:.|..::|:...|.:..|:|   ....||:.|:  |.::.....||.:
  Rat   130 DSSHKQRKKVIMQAFNREALQCYVPVIAEEVSGCLEQ---WLSCGERGLLVYPEVKRLMFRIAMR 191

  Fly   181 TTMGSDV------KDE----ESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAG-KESHYY 234
            ..:|.:.      :||    |:|             |.||...||..::..|.....| |..:..
  Rat   192 ILLGCEPGPAGGGEDEQQLVEAF-------------EEMTRNLFSLPIDVPFSGLYRGVKARNLI 243

  Fly   235 QAKTE--IRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGV-FTLKNVEDESNII 296
            .|:.|  ||..||::   :.||.:.|...::|.        |:.....||. ..::.::..|..:
  Rat   244 HARIEENIRAKIRRL---QAAEPDAGCKDALQL--------LIEHSWERGERLDMQALKQSSTEL 297

  Fly   297 VFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKT---IFPNTGDFDVSYADTQQMVYLDLILNE 358
            :||..||||:|....:..|.::|...::..||||:   :..:..:..:.....:|:.|:..::.|
  Rat   298 LFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKE 362

  Fly   359 SMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQ 423
            ::|:.||||...|...:..:| ||..:|||..:...|...|.....: .:.|.||||.|...:.:
  Rat   363 TLRLNPPVPGGFRVALKTFEL-NGYQIPKGWNVIYSICDTHDVADSF-TNKEEFNPDRFTSLHPE 425

  Fly   424 DKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNY---------RFKTS---FPFENL---- 472
            |...:::|||..|:|:|:|..:|.|..|:...:|.|..         ..|||   :|.:||
  Rat   426 DTSRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARRCDWQLLNGPPTMKTSPPVYPVDNLPARF 490

  Fly   473 -YFVEDI 478
             :|..||
  Rat   491 THFQGDI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	113/476 (24%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	120/495 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000