DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	512	Identity:	142/512 - (27%)
Similarity:	218/512 - (42%)	Gaps:	104/512 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LWCGLLFLL-----WIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRRE-DILNAFGCFLDK- 63
            ||..::.|:     .:..|:.|::........|||       ..|||.... :|....|  |||
Mouse    15 LWASVVILMVTVLKLLSLLFRRQKLARALDSFPGP-------PKHWLFGHALEIQKTGG--LDKV 70

  Fly    64 ----------HGPTIFSWLGP-IPFMIVSDPQVVQDIFT--SPHCVNKGIIYKAVDDGAGVGLFS 115
                      | |.   |||. |.|:.:.:|...:.:::  .|   ....:|.......|.||..
Mouse    71 VTWTEQFPYAH-PL---WLGQFIVFLNIYEPDYAKAVYSRGDP---KAAYVYDFFLQWIGKGLLV 128

  Fly   116 LKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK-DLIPLLQSFTLGIAT 179
            |:.|:|..|||||.|.|.:.||..::.||...|.::||:.|....:.:. |:...:....|....
Mouse   129 LEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLM 193

  Fly   180 QTTMGSDVKDEE--SFRSNSLLGRYQCILETMTDMC------------FSPWL---NSRFCR--Q 225
            :.|.|   |.:.  |...||    |...:..:|.:.            |..||   ..||.|  |
Mouse   194 KCTFG---KGDSGLSHSDNS----YYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQ 251

  Fly   226 LAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVE 290
            :|...:.:.     |||       ||.|..:......:|......||::           |....
Mouse   252 IAHDHTDHV-----IRQ-------RKAALQDEKEQKKLQERRHLDFLDI-----------LLGAR 293

  Fly   291 DESNI-------------IVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFD-V 341
            |||.|             .:|...:||.:.:.:.|..:|::|.:|:|..||::.|.   ||.| .
Mouse   294 DESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREIL---GDRDSF 355

  Fly   342 SYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWG 406
            .:.|..||.||.:.:.|..|:.||||.|.||.|:.:...:|..:|.|..|::.||.:||:..:|
Mouse   356 QWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW- 419

  Fly   407 PDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF 463
            ||.|.|:|..|.|.|:..:||:|::||:.|.|||||.::|:...||..|..|..:.|
Mouse   420 PDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEF 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	137/480 (29%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	137/480 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810