DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	524	Identity:	135/524 - (25%)
Similarity:	235/524 - (44%)	Gaps:	82/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLLFLL------WIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRRE------DILNAFGCFL 61
            |||.||      :::..|..:.|.    :.|.|   |.    ||....|      ::.....|.
Mouse    26 GLLLLLVKAVQFYLHRQWLLKAFQ----QFPSP---PF----HWFFGHEKFKGDQELQEIVSCI- 78

  Fly    62 DKHGPTIF-SWL-GPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIH 124
             ::.|:.| .|. |...::.|.||..::.|.........| .|:.:....|.||..|....|..|
Mouse    79 -ENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANG-AYRLLAPWIGYGLLLLNGQPWFQH 141

  Fly   125 RKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKD 189
            |::|.|||.:.:|..::........|:||:.|.|.|  :...|.:.|..:| :...|.|......
Mouse   142 RRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAD--QDSSIEIFQHISL-MTLDTVMKCAFSH 203

  Fly   190 EESFRSNSLLGRYQCILETMTDMCFSPWLNSRF---CRQLAGKESHYYQAKTEIRQFIRK----- 246
            :.|.:.:   |.|:..|:.:.|      ||:.|   .|.:..:....|:..:..|  :.|
Mouse   204 KGSVQVD---GNYRTYLQAIGD------LNNLFHSRVRNIFHQNDTIYKLSSNGR--LAKQACQL 257

  Fly   247 -------IIERKLAEDEM---GALPSIQSNDKNLFLN-LVTDLMRRG-VFTLKNVEDESNIIVFG 299
                   :|  ||.:|::   |.|..|:...:..||: |:...|..| ..:.|::..|.:..:|.
Mouse   258 AHDHTDGVI--KLRKDQLQDEGELEKIKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFE 320

  Fly   300 AFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMVYLDLILNESMRVI 363
            ..:|||:.|.:....||..|::|:|..||::::.   || ..:::....|:.|..:.:.|::|:.
Mouse   321 GHDTTASGVSWIFYALATHPDHQQRCREEVQSLL---GDGSSITWDHLDQIPYTTMCIKEALRLY 382

  Fly   364 PPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPY 428
            ||||.:.|:.|..:...:|..:|||||:.:.||.:|.:.|:| |:.|.|:|..|.|.:  .:|.:
Mouse   383 PPVPGIVRELSTSVTFPDGRSLPKGVQVTLSIYGLHHNPKVW-PNPEVFDPSRFAPDS--PRHSH 444

  Fly   429 AYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF-----KTSFPFENLYFVEDITMKLKSVPLL 488
            :::||:.|.|||||.::|:...||.:|..|..:..     :...|...|      .:|.|:...|
Mouse   445 SFLPFSGGARNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARL------VLKSKNGIYL 503

  Fly   489 ELQK 492
            .|:|
Mouse   504 HLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	121/465 (26%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	125/488 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810