Protein Alignment Cyp313a4 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 528
• Identity: 139/528 - (26%)
• Similarity: 236/528 - (44%)
• Gaps: 89/528 - (16%)

  Fly     3 TWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAF--------GC 59
            ||.|....|...:||..:|...|  ..|.||||...|:.|         .|.|.|        .|
Mouse    11 TWVLLVTSLVFFYIYGTYSHGLF--KKLGIPGPKPLPLFG---------TIFNYFDGMWKFDEDC 64

  Fly    60 FLDKHGPTIFSWLGPIPFMIVSDPQVVQ--------DIFTS-PHCVNKGIIYKAVDDGAGVGLFS 115
            : .|:|.....::||.|.:.:.||::::        .:||: |.....|.:.|::...
Mouse    65 Y-KKYGKIWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTLGPVGFLKKSITIS------- 121

  Fly   116 LKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSFTLG 176
             :|..|...|.||:|.|....|....||..:...:|:..|...::.||    ||   :..::::.
Mouse   122 -EDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKD---IFGAYSMD 182

  Fly   177 IATQTTMGSDVKDEESFRSNSLLGRYQCILETMTDMCFSPWLNSR----FCRQLAGKESHYYQAK 237
            :.|.|:.|.:: |..:...|..:.:.:.||:.   ..|.|:|.|.    |...:      |....
Mouse   183 VITGTSFGVNI-DSLNNPQNPFVQKTKKILKF---KIFDPFLLSTILFPFLTPI------YEMLN 237

  Fly   238 TEI-----RQFIRKIIERKLAEDEMGALPSIQSNDKNL--FLNLVTDLMR-RGVFTLKNVED--- 291
            ..|     ..|.:|.::|...|       .:.|..||.  ||.|:.:... :|..:.|.:.|
Mouse   238 LSIFPRDSMNFFKKFVKRMKKE-------RLASKQKNRVDFLQLMMNTQNSKGQESQKALSDLEM 295

  Fly   292 --ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDL 354
              ::.|.:||.::.|:.::...:..||..|:.|::..:||....||..  .|:|.....|.|||:
Mouse   296 AAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKA--PVTYDALMDMEYLDM 358

  Fly   355 ILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLP 419
            ::|||:|:.|....:.|.:.:|::: ||:.:|||..:.|.||.:||:.:.| |:.:.|.|..|..
Mouse   359 VVNESLRLYPTAIRLERVSKKDVEI-NGVFIPKGTVVMIPIYPLHRNPEYW-PEPQEFCPGRFSK 421

  Fly   420 HNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLKS 484
            .|..:..||.|:||..|.|||:..|:||||.|:.:..:|:|:   |..|.|.    ..|.:|:..
Mouse   422 ENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNF---TVQPCEE----TQIPLKISR 479

  Fly   485 VPLLELQK 492
            .|:.:.:|
Mouse   480 EPVFQPEK 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	118/453 (26%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	120/460 (26%)