DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dtg and gpatch3

DIOPT Version :9

Sequence 1:	NP_650220.2	Gene:	Dtg / 41558	FlyBaseID:	FBgn0038071	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_005158511.1	Gene:	gpatch3 / 791148	ZFINID:	ZDB-GENE-070112-902	Length:	688	Species:	Danio rerio

Alignment Length:	548	Identity:	101/548 - (18%)
Similarity:	180/548 - (32%)	Gaps:	186/548 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VVELKVAESNPVDPVEATDNFVSVYGGNLEQDIKNDVNSEVEDAPSPVEPIIEEVQKVAEAELEN 149
            ||.::..||         |.|:.:|.||  |.|.:..|                       .|.|
Zfish    79 VVSVRAQES---------DRFIRMYSGN--QWIDSSGN-----------------------WLRN 109

  Fly   150 ----HEIKLAVQSAREPKSLDAEEESKTIDEDRLENQDKAETVTDNIAVSSEQMESHIRPLPNVT 210
                ..::::.||                |.|....:.||| :..::|.|.:..|:.:|.||.:.
Zfish   110 TCLIRRVRVSEQS----------------DCDLFPYKTKAE-LRRHVAQSEQFTENDLRGLPELN 157

  Fly   211 SDLVSVILNEDKAITEQPITKTNLLALEQEHEKFEEIDESTTVPVYEEPKHQVTKKQGVEDPST- 274
            ...:....|....::                 .|.::.:|..:|    |:  :.:|.|:..|.|
Zfish   158 PPALMPSGNVGTPVS-----------------VFLQLIQSCRLP----PR--LIRKLGLTFPKTG 199

  Fly   275 -----VEIPPEVSDEQHFDPSEEPQTVRDERNLEEHDDNQNEINENIIEG--------EEAP--- 323
                 ..:|.:..:.:...|:||.........::.|.........:..:|        :|.|
Zfish   200 SNRRYGNVPYQYHNTRVVTPAEESVFTAGGVEIKGHAQRDTPTTSHRKQGKPTTLYRTQETPTAS 264

  Fly   324 -AKTSTTAGPLVTVEPTKSITEPNEE-------IEKKAEAEAKAE----MEEQVEVNTPS--VDA 374
             ||..|....| |::.|.:.|:.|::       |:....|..:.:    ..::::::|.|  :..
Zfish   265 QAKQDTPTISL-TIQDTPTTTQTNQDTPSTSCKIQDTPTASQRKQDTPTTSQKLDMSTTSCKIQD 328

  Fly   375 TVVAAD--PDEAQDEVIVAETTVEAITEAAKIVVEEEP----KEDVS-----VQQEHLKEQR--- 425
            |..|:.  .|......|:.:|...:.|      |::.|    |:|:|     :|......||
Zfish   329 TPTASQRKQDTPTTSCIIQDTPTTSQT------VQDTPTTSQKQDMSTTSCKIQDTPTASQRKDT 387

  Fly   426 ------VQ-TVSESNR----------QASPTEEPIKEVIFPKG----------------DDESPV 457
                  :| |.:.|.|          |.:||....|.:..|..                |..||.
Zfish   388 PPTSCIIQDTPTASQRKDTPPTSCIIQDTPTTSQTKRLNTPTASRKIQDTPTYTQTLYEDTPSPP 452

  Fly   458 EGDSSESDEKPTERAIVDDDSS--------EEQNEDVVDEGKSSSD----------DSTATPLVS 504
            ....|:.:|...|.:..|||..        |..:||:..:.:|...          :...:.||.
Zfish   453 VNQPSQEEESEEELSGPDDDDDRCEEWERHEALHEDITAQERSKERLFEEEIELKWEKGGSGLVF 517

  Fly   505 YPPHDAGQ-----TFDSNSADEHSAQLS 527
            |......|     .||..:||:....:|
Zfish   518 YTDAQFWQEEEEGDFDEQTADDWDVDMS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dtg	NP_650220.2	PTZ00341	<112..325	CDD:173534	36/234 (15%)
		rne	<303..445	CDD:236766	37/197 (19%)
		DUF3295	<410..>498	CDD:288540	29/150 (19%)
gpatch3	XP_005158511.1	RRM_SF	12..>31	CDD:302621
gpatch3	XP_005158511.1	G_patch	585..631	CDD:197727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900