DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dtg and Muc18B

DIOPT Version :9

Sequence 1:	NP_650220.2	Gene:	Dtg / 41558	FlyBaseID:	FBgn0038071	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001285431.1	Gene:	Muc18B / 32913	FlyBaseID:	FBgn0031000	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	215	Identity:	47/215 - (21%)
Similarity:	77/215 - (35%)	Gaps:	51/215 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 RDERNLEEHDDNQNEINENIIE--GEEAPAKTS--TTAGPLVTVEPTKSITEPNEEIEKKAEAEA 357
            ||:.|:|......:.::|:..|  ..|||..|.  |||.|..|.:.|.......|:|..:|....
  Fly    81 RDDSNIENPTIPPSNLDESTTEKPATEAPGTTEKVTTAAPGTTEKVTTEAPGTTEKITTEAPGTT 145

  Fly   358 KAEMEEQVEVNTPSVDATVVAADPDEAQDEVIVAETTVEAITEAAKIVVEEEPKEDVSVQQEHLK 422
                 |::....|.....:....|.          ||.:..|||..  ..|:|..|.
  Fly   146 -----EKITTEAPGTTEKITTEAPG----------TTEKITTEAPG--TTEKPATDA-------- 185

  Fly   423 EQRVQTVSESNRQASPTEEPIKEVIFPKGDDES-----PVEGDSSESDEKPTERAIVDDDSSEEQ 482
                         ...||:|..:.  |...::|     |...|.|::|...|:.....:.|::|.
  Fly   186 -------------PGTTEKPATDA--PGTTEKSETTDAPGTTDKSDTDAPITDEPSTAETSTDEP 235

  Fly   483 NEDVVDEGKSSS--DDSTAT 500
            |.:..:.|:.::  |:..||
  Fly   236 NTETTESGEETTIEDNVCAT 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dtg	NP_650220.2	PTZ00341	<112..325	CDD:173534	9/29 (31%)
		rne	<303..445	CDD:236766	30/145 (21%)
		DUF3295	<410..>498	CDD:288540	17/94 (18%)
Muc18B	NP_001285431.1	CBM_14	26..72	CDD:279884
Muc18B	NP_001285431.1	MCLC	<77..177	CDD:283562	27/112 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900