Protein Alignment Dtg and MUCL3

DIOPT Version :9

• Sequence 1: NP_650220.2
• Gene: Dtg / 41558
• FlyBaseID: FBgn0038071
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_543146.2
• Gene: MUCL3 / 135656
• HGNCID: 21666
• Length: 1393
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 143/659 - (21%)
• Similarity: 227/659 - (34%)
• Gaps: 186/659 - (28%)

  Fly    36 SCSAQPIE-----------STSLPAEVDD------VEGTTILPIQ---------LEESSPTP-EP 73
            |.||:|.|           :||.|||..:      .|.||..|.:         .|:::|.| ||
Human   796 SSSAEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPAEP 860

  Fly    74 I-----IKNETATALPVVELKVAESNP-------VDPVEATDNFVSVYGGNLEQDIKNDVNSEVE 126
            .     ..||..|..|....:..|..|       :.|.|.|:|      |.     :....:| :
Human   861 TENREWTANENTTLSPAEPTEHEEMTPLANEKTTLSPAEPTEN------GE-----RTPFTNE-K 913

  Fly   127 DAPSPVE--------PIIEEVQKVAEAELENHEIKLAVQSAREPKSLDAEEESKTIDEDRLENQD 183
            ..||..|        |:..|:...:.||...|..::|.:.|....:...|....|::||...:
Human   914 TTPSSAEPTEHGERTPLANEITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVNEDTTPS-- 976

  Fly   184 KAETVTDNIAVSSEQMESHIR-PLPNVTSDLVSVILNEDKAITEQPITKTNLLALEQEHEKFEEI 247
                       |:|..|:..| ||.|..:             |..|...|       ||.: ...
Human   977 -----------SAEPTENGERTPLANENT-------------TTSPTEST-------EHGE-RTA 1009

  Fly   248 DESTTVPVYEEPKHQVTKKQGVEDPS----TVEIPPEVSDEQHFDPSEEPQTVRDERNLEEHDDN 308
            :|.||....|..:|      |...||    |:..|.:.::.:...||....|........||.:.
Human  1010 NEKTTPSPAEPTEH------GERTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKPTEHGEK 1068

  Fly   309 QNEINENIIEGEEAP----AKTSTTAGPLVT---VEPT---KSITEPNEEIEKKAEAEAKAEMEE 363
            ....||.|....|.|    ||| |:|...:|   .:||   :..|.||::|...|     ||..|
Human  1069 TTLANEKITLSPEGPTEHGAKT-TSANEKITPSLAKPTEHGERTTSPNDKITSSA-----AESTE 1127

  Fly   364 QVEVNTPSVDATVVAADPDEAQDEVIVAETTVEAITEAAKIVVEEEPKEDVSVQQEHLKEQRVQT 428
            ..:..|.:...|...|:|.:......:|...:..:||.:    .|.|::..|..::..:.....|
Human  1128 HRDRATSANVITPAPAEPIKHAKRTTLAHEKMTQVTEKS----TEHPEKTTSTTEKTTRTPEKPT 1188

  Fly   429 V-------------------SESNRQASPTEEPIKEVIFPKGDDESPVEGDSSESDEKPTERAIV 474
            :                   :|:....:.|.|.||.   |....|:|.:..:.....||:.:...
Human  1189 LYSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKA---PVKSTENPEKTAAVTKTIKPSVKVTG 1250

  Fly   475 DDD---SSEEQNED-------------VVDEGKSSSDDSTATPLVSYPPHDAGQTFDSNSADEHS 523
            |..   :|...|:.             :....|.||..|.||...|:|..:.    |.:....|:
Human  1251 DKSLTTTSSHLNKTEVTHQVPTGSFTLITSRTKLSSITSEATGNESHPYLNK----DGSQKGIHA 1311

  Fly   524 AQLSGATNYRSTLIIALCSGTAVIFIVASLVIFVVSF-QRQHGTL-------DIE---------- 570
            .|:....::.:..|:.:.....::.:|...:||:||: .|...||       |.|
Human  1312 GQMGENDSFPAWAIVIVVLVAVILLLVFLGLIFLVSYMMRTRRTLTQNTQYNDAEDEGGPNSYPV 1376

  Fly   571 --MQEQRLG 577
              |::|.||
Human  1377 YLMEQQNLG 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dtg	NP_650220.2	PTZ00341	<112..325	CDD:173534	47/229 (21%)
		rne	<303..445	CDD:236766	38/170 (22%)
		DUF3295	<410..>498	CDD:288540	19/122 (16%)
MUCL3	NP_543146.2	Atrophin-1	<299..820	CDD:331285	7/23 (30%)
		LGT	<916..1062	CDD:320995	39/185 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900