DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6753 and LIPF

DIOPT Version :9

Sequence 1:	NP_650219.2	Gene:	CG6753 / 41557	FlyBaseID:	FBgn0038070	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001185758.1	Gene:	LIPF / 8513	HGNCID:	6622	Length:	408	Species:	Homo sapiens

Alignment Length:	354	Identity:	133/354 - (37%)
Similarity:	209/354 - (59%)	Gaps:	8/354 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GYNVERHSVTTKDGYVLTLHRIPQVDPELGSLLRRPVVFLLSGLYASSDVWLLNGREDSLAYLLW 107
            ||..|.:.|.|:|||:|.::|||......|:..:||||||..||.||:..|:.|...:|||::|.
Human    53 GYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILA 117

  Fly   108 RAGYDVWLGNNRGNIYCRKNMWRNTTEREFWDFSWHEMGVYDLPAQVDYVLRTTGQKAMHFVGIS 172
            .|||||||||:|||.:.|:|::.:....|||.||:.||..|||||.:|::::.||||.:|:||.|
Human   118 DAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHS 182

  Fly   173 QGGTVFLVLNSMMPQYNAVFKSATLLAPVAYVSNTKSGLAKVIGPVLGTRNYVSKMLEGVEMFST 237
            ||.|:..:..|..|......|:...|||||.|..|||    :|..:......:.|.:.|.::|..
Human   183 QGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKS----LINKLRFVPQSLFKFIFGDKIFYP 243

  Fly   238 NKFFKKFLSM-TCLENEKPLVCISRLWPAVGYDTRFLNKTLLPDLMANFPAGGSVKQLMHYFQGY 301
            :.||.:||:. .|......|:|.:.|:...|:|::..|.:.|...:::.|||.||:.:.|:.|..
Human   244 HNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAV 308

  Fly   302 VSTRFRQYDYG-PERNWLHYQQLEPPEYALENVSTPVTVFFSENDYIVAPADIWRLLTRLPNVEA 365
            .|.:|:.||:| |.:|.:||.|.:||.|.:..::.|:.|:....|.:..|.|:..||.:|||:..
Human   309 KSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIY 373

  Fly   366 VYKVPWKRWNHFDFICGLGVREYIFDNIV 394
            ..::|:  :||.|||..:...:.::::||
Human   374 HKEIPF--YNHLDFIWAMDAPQEVYNDIV 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6753	NP_650219.2	PLN02872	39..394	CDD:215470	131/352 (37%)
LIPF	NP_001185758.1	PLN02872	14..400	CDD:215470	131/352 (37%)
		Abhydro_lipase	45..107	CDD:282003	24/53 (45%)
		Abhydrolase_5	88..>211	CDD:289465	58/122 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141734
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910