DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6753 and LIPK

DIOPT Version :9

Sequence 1:	NP_650219.2	Gene:	CG6753 / 41557	FlyBaseID:	FBgn0038070	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	XP_011538375.1	Gene:	LIPK / 643414	HGNCID:	23444	Length:	419	Species:	Homo sapiens

Alignment Length:	363	Identity:	128/363 - (35%)
Similarity:	204/363 - (56%)	Gaps:	10/363 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GYNVERHSVTTKDGYVLTLHRIPQVDPELGSLLRRPVVFLLSGLYASSDVWLLNGREDSLAYLLW 107
            ||..|.:.|||||||:|.::|||......|....:|.|:|..||.||:..|:.|...:|||:||.
Human    63 GYPYEEYDVTTKDGYILGIYRIPHGRGCPGRTAPKPAVYLQHGLIASASNWICNLPNNSLAFLLA 127

  Fly   108 RAGYDVWLGNNRGNIYCRKNMWRNTTEREFWDFSWHEMGVYDLPAQVDYVLRTTGQKAMHFVGIS 172
            .:||||||||:|||.:.||::..:....|:|.||..||..|||||.:::::..||||.:::||.|
Human   128 DSGYDVWLGNSRGNTWSRKHLKLSPKSPEYWAFSLDEMAKYDLPATINFIIEKTGQKRLYYVGHS 192

  Fly   173 QGGTVFLVLNSMMPQYNAVFKSATLLAPVAYVSNTKSGLAKVIGPVLGTRNYVSKMLEGVEMFST 237
            ||.|:..:..|..|:.....|....||||..|..|:|.:.|:  ..|..|  |.|:|.|.:||..
Human   193 QGTTIAFIAFSTNPELAKKIKIFFALAPVVTVKYTQSPMKKL--TTLSRR--VVKVLFGDKMFHP 253

  Fly   238 NKFFKKFLSMTCLENEKPL--VCISRLWPAVGYDTRFLNKTLLPDLMANFPAGGSVKQLMHYFQG 300
            :..|.:|:: |.:.|.|..  :|.:.|:...|:|.:.||.:.|...:::.|||.||:.::|:.|.
Human   254 HTLFDQFIA-TKVCNRKLFRRICSNFLFTLSGFDPQNLNMSRLDVYLSHNPAGTSVQNMLHWAQA 317

  Fly   301 YVSTRFRQYDYG-PERNWLHYQQLEPPEYALENVSTPVTVFFSENDYIVAPADIWRLLTRLPNVE 364
            ..|.:.:.:|:| .::|.:|:.||.||.|.:..:..|..::....|.:..|.|:..||.::.|:.
Human   318 VNSGQLQAFDWGNSDQNMMHFHQLTPPLYNITKMEVPTAIWNGGQDIVADPKDVENLLPQIANLI 382

  Fly   365 AVYKVPWKRWNHFDFICGLGVREYIFDNIVLSMNRYEQ 402
            ....:|  .:||.||..|....:.|:.::::.|..|.|
Human   383 YYKLIP--HYNHVDFYLGEDAPQEIYQDLIILMEEYLQ 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6753	NP_650219.2	PLN02872	39..394	CDD:215470	125/353 (35%)
LIPK	XP_011538375.1	PLN02872	31..410	CDD:215470	125/353 (35%)
		Abhydro_lipase	55..117	CDD:282003	23/53 (43%)
		Abhydrolase_5	99..>246	CDD:289465	62/150 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141778
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910