DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6753 and Lipa

DIOPT Version :9

Sequence 1:	NP_650219.2	Gene:	CG6753 / 41557	FlyBaseID:	FBgn0038070	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001104570.1	Gene:	Lipa / 16889	MGIID:	96789	Length:	397	Species:	Mus musculus

Alignment Length:	376	Identity:	130/376 - (34%)
Similarity:	204/376 - (54%)	Gaps:	19/376 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITDAVRRIQNDGYNVERHSVTTKDGYVLTLHRIPQVDPELGSLLRRPVVFLLSGLYASSDVWLLN 96
            :|:.:.|.   ||..|.|||.|.|||:|::||||:..........||||:|..||.|.|..|:.|
Mouse    35 VTEIIMRW---GYPGEEHSVLTGDGYILSIHRIPRGRKNHFGKGPRPVVYLQHGLLADSSNWVTN 96

  Fly    97 GREDSLAYLLWRAGYDVWLGNNRGNIYCRKNMWRNTTEREFWDFSWHEMGVYDLPAQVDYVLRTT 161
            ....||.:||..||:|||:||:|||.:..|:...:.::.|||.||:.||..|||||.::|:|..|
Mouse    97 IDNSSLGFLLADAGFDVWMGNSRGNTWSLKHKTLSVSQDEFWAFSFDEMAKYDLPASINYILNKT 161

  Fly   162 GQKAMHFVGISQGGTVFLVLNSMMPQYNAVFKSATLLAPVAYVSNTKSG----LAKVIGPVLGTR 222
            ||:.:::||.|||.|:..:..|.||:.....|...:||||..: |..||    |.::..|:|
Mouse   162 GQEQIYYVGHSQGCTIGFIAFSQMPELAKKIKMFLVLAPVLSL-NFASGPLLQLGRLPDPLL--- 222

  Fly   223 NYVSKMLEGVEMFSTNKFFKKFLSM-TCLENEKPLVCISRLWPAVGYDTRFLNKTLLPDLMANFP 286
                |.:.|.:.|.......|:||: .|.......:|.:..:...|::.:.||.:.:.....:.|
Mouse   223 ----KDMFGQKQFLPQSAMLKWLSIHVCTHVIMKELCANVFFLLCGFNEKNLNMSRVDVYTTHCP 283

  Fly   287 AGGSVKQLMHYFQGYVSTRFRQYDYG-PERNWLHYQQLEPPEYALENVSTPVTVFFSENDYIVAP 350
            ||.||:.::|:.|.:...:.:.:|:| .|:|:.||.|..||.|.::|:..|..::....|::...
Mouse   284 AGTSVQNMLHWGQVFKYRKLQAFDWGSSEKNYFHYNQSFPPSYNIKNMRLPTALWSGGRDWLADI 348

  Fly   351 ADIWRLLTRLPNVEAVYKVPWKRWNHFDFICGLGVREYIFDNIVLSMNRYE 401
            .||..|||::|.:  ||......|:|.|||.||.....::|.|:..|.:|:
Mouse   349 NDITILLTQIPKL--VYHKNIPEWDHLDFIWGLDAPWKLYDEIISLMKKYQ 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6753	NP_650219.2	PLN02872	39..394	CDD:215470	125/360 (35%)
Lipa	NP_001104570.1	PLN02872	6..394	CDD:215470	128/371 (35%)
		Abhydro_lipase	35..96	CDD:282003	27/63 (43%)
		Abhydrolase_5	78..>192	CDD:289465	51/113 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860