DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6753 and LIPJ

DIOPT Version :9

Sequence 1:	NP_650219.2	Gene:	CG6753 / 41557	FlyBaseID:	FBgn0038070	Length:	405	Species:	Drosophila melanogaster
Sequence 2:	NP_001010939.2	Gene:	LIPJ / 142910	HGNCID:	21773	Length:	366	Species:	Homo sapiens

Alignment Length:	367	Identity:	126/367 - (34%)
Similarity:	198/367 - (53%)	Gaps:	33/367 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GYNVERHSVTTKDGYVLTLHRIP--QVDPELGSLLRRPVVFLLSGLYASSDVWLLNGREDSLAYL 105
            ||..|.:.:.|:|||:|.|:|||  :.|.. .:|.:|.||:|..||..|:..|:.|...:||.::
Human    11 GYPDEEYDIVTEDGYILGLYRIPYWRTDNN-KNLAQRVVVYLQHGLLTSASSWISNLPNNSLGFI 74

  Fly   106 LWRAGYDVWLGNNRGNIYCRKNMWRNTTEREFWDFSWHEMGVYDLPAQVDYVLRTTGQKAMHFVG 170
            |..||||||:||:|||.:.||:::..|:.:|||.||:.||..|||||.:|:.::.|.|:.:.:||
Human    75 LADAGYDVWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFTVKQTRQEEIFYVG 139

  Fly   171 ISQGGTVFLVLNSMMPQYNAVFKSATLLAPVAYVSNTKSGLAKVIGPVLGTRNYVSKMLEGVEMF 235
            .|||.|:..:..|.:.:.....|....||||......||.|.::        .|..|.:  |..|
Human   140 HSQGTTIGFITFSTISKIAERIKIFFALAPVFSTKYLKSPLIRM--------TYKWKSI--VMAF 194

  Fly   236 STNK------FFKKFL-SMTCLENEKPL-----VCISRLWPAVGYDTRFLNKTLLPDLMANFPAG 288
            |.||      .||||: |..|     ||     :|::.|:...|||.:.||.:.|....::.|||
Human   195 SGNKDFLPKTSFKKFIGSKLC-----PLQIFDKICLNILFMMFGYDPKNLNMSRLDVYFSHNPAG 254

  Fly   289 GSVKQLMHYFQGYVSTRFRQYDYG-PERNWLHYQQLEPPEYALENVSTPVTVFFSENDYIVAPAD 352
            .||:.::|:.|...||..:.||:| |:.|.:||.|...|.|.:.|::....::..::|.:..|.|
Human   255 TSVQNMLHWSQLLNSTHLKAYDWGSPDLNLVHYNQTTSPLYNMTNMNVATAIWNGKSDLLADPED 319

  Fly   353 IWRLLTRLPNVEAVYKVPWKRWNHFDFICGLGVREYIFDNIV 394
            :..|.:.:.|  .:|......:||.|.:.||.|.:.::..|:
Human   320 VNILHSEITN--HIYYKTISYYNHIDSLFGLDVYDQVYHEII 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6753	NP_650219.2	PLN02872	39..394	CDD:215470	125/365 (34%)
LIPJ	NP_001010939.2	Abhydro_lipase	3..66	CDD:282003	22/55 (40%)
		Abhydrolase_5	47..209	CDD:289465	64/171 (37%)
		Abhydrolase_1	48..347	CDD:278959	107/315 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141756
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.910