Protein Alignment Not10 and Not10

DIOPT Version :10

• Sequence 1: NP_650215.1
• Gene: Not10 / 41552
• FlyBaseID: FBgn0260444
• Length: 635
• Species: Drosophila melanogaster
• Sequence 2: XP_318732.5
• Gene: Not10 / 1279063
• VectorBaseID: AGAMI1_012990
• Length: 638
• Species: Anopheles gambiae
• Alignment Length: 655
• Identity: 209/655 - (31%)
• Similarity: 333/655 - (50%)
• Gaps: 69/655 - (10%)

  Fly     3 SAESPTKTQAGEDENYSLLCQAHEQFNNSEFDRCLELLQELETRGESSGPVLRHNRAVVSYYKTG 67
            ||:.|:.    .|:...|..||..:|..:::..|.:.||:| .:.:.|.|.:.||||||.:|.:.
Mosquito     6 SAKKPSL----NDQERDLEQQAFIEFQKADYHACYQTLQKL-LKTQDSNPKVLHNRAVVEFYNSD 65

  Fly    68 CTQHSVLLKELEALTADADAPGDVSSGLSLKQGAAAATVARYNRAVIYYHRHMFGTALEKLAPLV 132
            ..::.   :...|:.......|::.: :.:|...:.|  |..|:|::.||......||:.:..::
Mosquito    66 LRRYD---QFRSAMIQQTGLVGEIRT-VEVKDRESCA--AYVNQAIVLYHFKQPLAALKIMLAVM 124

  Fly   133 ARLEALEKAMAALVATLQLQLLLATNQLNRAEAFLDYLQYKLNLVATAPSSNAAEEAAVVGTAPP 197
            |..:.|:..:........:.|||.|||..:|...|..||.:|.:...|..|::.|:..::.....
Mosquito   125 AHFDRLDDYLLRRAGIFTVHLLLDTNQPKKANRLLGMLQNRLGIQVYAILSDSDEDEPLIDNESR 189

  Fly   198 SAATNSSVVASPGGAAVEGAVPGLGGSLQLLQLITLVLN-RKPVVIQEDGTPEYAALKAQQYYIM 261
            ...:             |..........:|:.:.:.:|| :|.:.|..:.|.||:.||..||::.
Mosquito   190 KDIS-------------ELQFEEFRKEFRLILIRSNLLNGKKNMSIPLEDTSEYSILKGHQYFLG 241

  Fly   262 KDFQMAAKQLMR-INNECTQAGTITPQLSTCIANNMGVIHLRVRHYAIAAKFFQNALNFDQQLAR 325
            .|:|||||:|.: ..||...........:|.:||||||||..|:|||:||:|||.||.||:....
Mosquito   242 NDYQMAAKELSKQFTNEPVSVNRHGEDQNTILANNMGVIHFSVKHYALAARFFQQALLFDKSATE 306

  Fly   326 N-----LRQSTLQTMSSARSCEILYNLGVAMLHLRRPKEAFQCFLVPVKQFHSNPRLWLRMAEAC 385
            :     :..|.|..:.:.:..|||||.|:|:|||:||||||:|.|:.:...|:|||||||:||.|
Mosquito   307 DTSTERVEGSPLYCVGATKRPEILYNHGLALLHLQRPKEAFECMLIVLNSNHNNPRLWLRLAECC 371

  Fly   386 IMEHEAKLVEEERQSQSET-----------------PSTK---PYAPQSAGVPEPTLEFAVLCLR 430
            ||.|     .:|:|:|:.:                 ||.|   |...||..:|..||||..||||
Mosquito   372 IMVH-----RQEKQTQNASICHGTVGCGVHRKYVLNPSPKTAVPEGDQSLAIPATTLEFGALCLR 431

  Fly   431 SALTLTQHYKTRFHMAAVSSEDVEAPEPKDPTQESWRHPQDNNFCNPSKPVSLESLENMMAAIYA 495
            :|:.|.::::         .|.:...|..|.| .:|....:...||||.|:.|.|...:..|:.|
Mosquito   432 NAVALLEYHE---------PELIRQTESSDKT-VAWDKVYEGVPCNPSLPMKLVSFNKLKCAVLA 486

  Fly   496 AHSFVSLRLGDHVTALEMSEKLLACERLSDAHKLLGHMYAGEALMLMDKASEARDHLDPTFVGTL 560
            |:|:|...||::..||:.::::|..:.|..::.||.||||.|||::|::..||..:|:|.|:..|
Mosquito   487 AYSYVLNTLGEYSLALKYAKQMLTMKDLPQSYLLLSHMYAAEALIMMNRPLEAITYLEPKFITEL 551

  Fly   561 NAFDFETR---DWQLKSVDAAQNVVRYNLAVAMALQNDLPQAKALLANLTHSLVANKALALRRFM 622
            ...||..|   .|.:.|.|||::|:.||.||...|..|..|||..:::..|.||......|..:.
Mosquito   552 AGDDFGMRASPHWNINSADAARSVMHYNRAVVSFLIGDYEQAKIAMSSCNHPLVMPYLKMLNVYQ 616

  Fly   623 DLKMG 627
            :|.:|
Mosquito   617 ELLLG 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Not10	NP_650215.1	Spy	294..>382	CDD:443119	48/92 (52%)
		TPR repeat	294..318	CDD:276809	17/23 (74%)
		TPR repeat	323..370	CDD:276809	20/51 (39%)
Not10	XP_318732.5	None