DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha55 and ATP6V1B2

DIOPT Version :9

Sequence 1:	NP_001163597.1	Gene:	Vha55 / 41550	FlyBaseID:	FBgn0005671	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001684.2	Gene:	ATP6V1B2 / 526	HGNCID:	854	Length:	511	Species:	Homo sapiens

Alignment Length:	481	Identity:	437/481 - (90%)
Similarity:	453/481 - (94%)	Gaps:	1/481 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 REHVLAVSRDFISQPRLTYKTVSGVNGPLVILDEVKFPKFAEIVQLRLADGTVRSGQVLEVSGSK 72
            ||..|||||:::|||||||||||||||||||||.||||::||||.|.|.|||.||||||||||||
Human    29 REQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSK 93

  Fly    73 AVVQVFEGTSGIDAKNTLCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPPILAEDFLDIQGQPI 137
            |||||||||||||||.|.|||||||||||||||||||||||||||||:||.:||||||||.||||
Human    94 AVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPI 158

  Fly   138 NPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKLPGKSVLDD 202
            ||..||||||||||||||||.||||||||||||||||||||||||||||||||||| ..|.|:|.
Human   159 NPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVK-KSKDVVDY 222

  Fly   203 HTDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTAAEFLAY 267
            ..:||||||||||||||||||||.||||||||:|||||||||||||||||||||||||.||||||
Human   223 SEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAY 287

  Fly   268 QCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIP 332
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   288 QCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIP 352

  Fly   333 ILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPVNVLPSLSRLMKSAIGEGMTRKDHSD 397
            |||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||:|
Human   353 ILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHAD 417

  Fly   398 VSNQLYACYAIGKDVQAMKAVVGEEALTPDDLLYLEFLTKFEKNFISQGNYENRTVFESLDIGWQ 462
            ||||||||||||||||||||||||||||.|||||||||.|||:|||:||.||||||||:||||||
Human   418 VSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQ 482

  Fly   463 LLRIFPKEMLKRIPASILAEFYPRDS 488
            ||||||||||||||.|.|:|||||||
Human   483 LLRIFPKEMLKRIPQSTLSEFYPRDS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha55	NP_001163597.1	V-ATPase_V1_B	25..488	CDD:273410	423/462 (92%)
ATP6V1B2	NP_001684.2	V-ATPase_V1_B	46..509	CDD:273410	425/464 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147954
Domainoid	1	1.000	423	1.000	Domainoid score	I620
eggNOG	1	0.900	-	-		E1_COG1156
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1279
Inparanoid	1	1.050	864	1.000	Inparanoid score	I429
Isobase	1	0.950	-	0	Normalized mean entropy	S50
OMA	1	1.010	-	-		QHG62168
OrthoDB	1	1.010	-	-		D276622at33208
OrthoFinder	1	1.000	-	-		FOG0001501
OrthoInspector	1	1.000	-	-		otm42087
orthoMCL	1	0.900	-	-		OOG6_100544
Panther	1	1.100	-	-	LDO	PTHR43389
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1629
SonicParanoid	1	1.000	-	-		X1067
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750