DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha55 and atp6v1ba

DIOPT Version :9

Sequence 1:	NP_001163597.1	Gene:	Vha55 / 41550	FlyBaseID:	FBgn0005671	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_878298.1	Gene:	atp6v1ba / 359839	ZFINID:	ZDB-GENE-030711-3	Length:	506	Species:	Danio rerio

Alignment Length:	489	Identity:	431/489 - (88%)
Similarity:	452/489 - (92%)	Gaps:	3/489 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QQAQREHVLAVSRDFISQPRLTYKTVSGVNGPLVILDEVKFPKFAEIVQLRLADGTVRSGQVLEV 68
            :.|.|:|..||.|::||||||||.|||||||||||||.||||::||||.|.|.|||.||||||||
Zfish    16 EAAARQHAQAVVRNYISQPRLTYTTVSGVNGPLVILDNVKFPRYAEIVHLTLPDGTKRSGQVLEV 80

  Fly    69 SGSKAVVQVFEGTSGIDAKNTLCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPPILAEDFLDIQ 133
            .|:||||||||||||||||.|.|||||||||||||||||||||||||||||:||..||||:|||.
Zfish    81 IGTKAVVQVFEGTSGIDAKKTACEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPTGLAEDYLDIM 145

  Fly   134 GQPINPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKLPGKS 198
            ||||||..||||||||||||||||.||||||||||||||||||||||||||||||||||: ..|.
Zfish   146 GQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVQ-KSKD 209

  Fly   199 VLDDHTDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTAAE 263
            |.|..::||||||||||||||||||||.||||||||:|||||||||||||||||||||||||.||
Zfish   210 VTDYSSENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAE 274

  Fly   264 FLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSI 328
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   275 YLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSI 339

  Fly   329 TQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPVNVLPSLSRLMKSAIGEGMTRK 393
            ||||||||||||||||||||||||||||:||||||||||||||:|||||||||||||||||||||
Zfish   340 TQIPILTMPNDDITHPIPDLTGYITEGQVYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRK 404

  Fly   394 DHSDVSNQLYACYAIGKDVQAMKAVVGEEALTPDDLLYLEFLTKFEKNFISQGNYENRTVFESLD 458
            ||:|||||||||||||||||||||||||||||.|||||||||.|||||||:||.|:|||.||:||
Zfish   405 DHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFIAQGAYDNRTAFETLD 469

  Fly   459 IGWQLLRIFPKEMLKRIPASILAEFYPRDS--RH 490
            ||||||||||||||||||.|.|||||||:|  ||
Zfish   470 IGWQLLRIFPKEMLKRIPQSTLAEFYPRESAARH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha55	NP_001163597.1	V-ATPase_V1_B	25..488	CDD:273410	416/462 (90%)
atp6v1ba	NP_878298.1	V-ATPase_V1_B	37..500	CDD:273410	416/463 (90%)
		ATP-synt_ab_N	41..107	CDD:280947	54/65 (83%)
		V_A-ATPase_B	109..392	CDD:238555	259/283 (92%)
		ATP-synt_ab_C	408..494	CDD:278722	76/85 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581851
Domainoid	1	1.000	426	1.000	Domainoid score	I591
eggNOG	1	0.900	-	-		E1_COG1156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	878	1.000	Inparanoid score	I385
OMA	1	1.010	-	-		QHG62168
OrthoDB	1	1.010	-	-		D276622at33208
OrthoFinder	1	1.000	-	-		FOG0001501
OrthoInspector	1	1.000	-	-		otm26300
orthoMCL	1	0.900	-	-		OOG6_100544
Panther	1	1.100	-	-	LDO	PTHR43389
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1067
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770