DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha55 and Atp6v1b1

DIOPT Version :9

Sequence 1:	NP_001163597.1	Gene:	Vha55 / 41550	FlyBaseID:	FBgn0005671	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_598918.1	Gene:	Atp6v1b1 / 110935	MGIID:	103285	Length:	513	Species:	Mus musculus

Alignment Length:	479	Identity:	414/479 - (86%)
Similarity:	445/479 - (92%)	Gaps:	1/479 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 REHVLAVSRDFISQPRLTYKTVSGVNGPLVILDEVKFPKFAEIVQLRLADGTVRSGQVLEVSGSK 72
            :|||.||:|::|:.||:||:||..||||||:||:|||.::||||...|.|||.||||||||:|:|
Mouse    23 QEHVQAVTRNYITHPRVTYRTVCSVNGPLVVLDQVKFAQYAEIVNFTLPDGTQRSGQVLEVAGTK 87

  Fly    73 AVVQVFEGTSGIDAKNTLCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPPILAEDFLDIQGQPI 137
            |:|||||||||||::.|.|||||||||||||||||||:||||||||||||.::||:||||.||||
Mouse    88 AIVQVFEGTSGIDSQKTTCEFTGDILRTPVSEDMLGRIFNGSGKPIDKGPAVMAEEFLDINGQPI 152

  Fly   138 NPWSRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKLPGKSVLDD 202
            ||..|||||||||||||.|||||||||||||||||||||||||||||||||||||| ..|:|||.
Mouse   153 NPHDRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVK-KSKAVLDY 216

  Fly   203 HTDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTAAEFLAY 267
            |.|||||||||||||||||||||.|||:||:|.|||||||||||||||||||||||||.||||||
Mouse   217 HEDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAY 281

  Fly   268 QCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIP 332
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||
Mouse   282 QCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIP 346

  Fly   333 ILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPVNVLPSLSRLMKSAIGEGMTRKDHSD 397
            ||||||||||||||||||:||||||||||||||||:|||:|||||||||||||||||||||||.|
Mouse   347 ILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQVYPPINVLPSLSRLMKSAIGEGMTRKDHGD 411

  Fly   398 VSNQLYACYAIGKDVQAMKAVVGEEALTPDDLLYLEFLTKFEKNFISQGNYENRTVFESLDIGWQ 462
            ||||||||||||||||||||||||||||.:||||||||.|||||||:||.|||||||||||:||:
Mouse   412 VSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFITQGPYENRTVFESLDLGWK 476

  Fly   463 LLRIFPKEMLKRIPASILAEFYPR 486
            ||||||||||||||.|:..|||.|
Mouse   477 LLRIFPKEMLKRIPQSMTDEFYSR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha55	NP_001163597.1	V-ATPase_V1_B	25..488	CDD:273410	405/462 (88%)
Atp6v1b1	NP_598918.1	V-ATPase_V1_B	40..504	CDD:273410	405/462 (88%)
		ATP-synt_ab_N	44..110	CDD:280947	46/65 (71%)
		V_A-ATPase_B	112..395	CDD:238555	259/283 (92%)
		ATP-synt_ab_C	410..505	CDD:278722	78/91 (86%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P15313	510..513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	423	1.000	Domainoid score	I623
eggNOG	1	0.900	-	-		E1_COG1156
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62168
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001501
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100544
Panther	1	1.100	-	-	LDO	PTHR43389
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1067
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780