DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and S1PR2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_004221.3	Gene:	S1PR2 / 9294	HGNCID:	3169	Length:	353	Species:	Homo sapiens

Alignment Length:	401	Identity:	98/401 - (24%)
Similarity:	156/401 - (38%)	Gaps:	115/401 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIM--VAIMAMTFNFSVQVT 216
            |..||:::| ..|.:..||||:|:|.|..|.......|:.:||.:|::  ||.:|.|. .|..||
Human    35 VASAFIVIL-CCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTL-LSGSVT 97

  Fly   217 GR-----W---NFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIM 273
            .|     |   ..|.|:.          .:||:..|..|:::|:.||.|...|....:.|:: ::
Human    98 LRLTPVQWFAREGSAFIT----------LSASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LL 151

  Fly   274 LLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTY 338
            :..:|:...:|..||| :||.        .:.:...||.|:..|       ...::.|.:.||:.
Human   152 IGASWLISLVLGGLPI-LGWN--------CLGHLEACSTVLPLY-------AKHYVLCVVTIFSI 200

  Fly   339 LAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKM 403
            :.:...|.......::|..:|.:                .:.:||.|
Human   201 ILLAIVALYVRIYCVVRSSHADM----------------AAPQTLAL------------------ 231

  Fly   404 KREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYF------NSTLNP 462
                  .:|:.|::|.||:||||.|....|...|.....|     ||:...||      ||.|||
Human   232 ------LKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCP-----ILYKAHYFFAVSTLNSLLNP 285

  Fly   463 LIYAYFNRDFREAFRNTLLCLFCNWWK--------------DRH-LPLDIDIRRSSLRYDQRAKS 512
            :||.:.:||.|......|.|     |:              ..| |||     |||...::....
Human   286 VIYTWRSRDLRREVLRPLQC-----WRPGVGVQGRRRGGTPGHHLLPL-----RSSSSLERGMHM 340

  Fly   513 VYSESYLNSTT 523
            ..|.::|...|
Human   341 PTSPTFLEGNT 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	48/187 (26%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	75/310 (24%)
S1PR2	NP_004221.3	7tmA_S1PR2_Edg5	34..299	CDD:320469	85/337 (25%)
		TM helix 1	35..61	CDD:320469	11/26 (42%)
		TM helix 2	68..93	CDD:320469	8/25 (32%)
		TM helix 3	105..135	CDD:320469	9/39 (23%)
		TM helix 4	146..166	CDD:320469	3/20 (15%)
		TM helix 5	186..215	CDD:320469	5/35 (14%)
		TM helix 6	226..256	CDD:320469	13/53 (25%)
		TM helix 7	267..292	CDD:320469	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910