DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and GPR50

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_004215.2	Gene:	GPR50 / 9248	HGNCID:	4506	Length:	617	Species:	Homo sapiens

Alignment Length:	425	Identity:	104/425 - (24%)
Similarity:	176/425 - (41%)	Gaps:	76/425 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 IVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQV 215
            |:::|.|  |::.|:..:.||.:||::|.:.:|||...|.|||||::||::|||...........
Human    28 IIFMFCA--MVITIVVDLIGNSMVILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMS 90

  Fly   216 TGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWIS 280
            .|.|:.|...|.:...:.......||.::..|:::||..|...|:|....:.|...|.|:.|||.
Human    91 IGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIM 155

  Fly   281 PALLSFLP-IFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFRE 344
             .:|:.|| ::||...........|.|     ::.|..:.|....|.|.:|..|:.|.|:.|:
Human   156 -TVLAVLPNMYIGTIEYDPRTYTCIFN-----YLNNPVFTVTIVCIHFVLPLLIVGFCYVRIW-- 212

  Fly   345 ANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKA 409
                .|.|..|            .|:|:                      ..|..|.:::.
Human   213 ----TKVLAAR------------DPAGQ----------------------NPDNQLAEVRN---- 235

  Fly   410 ARTLGIIMGTFILCWLPF-FLWYTLSMTCEEC--QVPDIVVSILFWIGYFNSTLNPLIYAYFNRD 471
            ..|:.:|...|.:||.|. .|...::::.:|.  ::|:.:....::|.||||.||.:||...|.:
Human   236 FLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN 300

  Fly   472 FREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQMVDNL 536
            ||..:......:       ||..:......|.:|..|.|:::       :...:|.|     |..
Human   301 FRREYWTIFHAM-------RHPIIFFSGLISDIREMQEARTL-------ARARAHAR-----DQA 346

  Fly   537 XYRDEALLTPIAQQQQRLAAGGSRLGGQLAAAAKD 571
            ..:|.|...| |.::..:......|.|..||...|
Human   347 REQDRAHACP-AVEETPMNVRNVPLPGDAAAGHPD 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	53/178 (30%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	76/298 (26%)
GPR50	NP_004215.2	7tm_4	39..>198	CDD:304433	48/164 (29%)
		7tm_1	45..294	CDD:278431	76/298 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..438		12/47 (26%)
		DUF4045	<364..600	CDD:289995	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910