DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and gpbar1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_009303247.3	Gene:	gpbar1 / 797190	ZFINID:	ZDB-GENE-120315-1	Length:	355	Species:	Danio rerio

Alignment Length:	411	Identity:	101/411 - (24%)
Similarity:	158/411 - (38%)	Gaps:	90/411 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SGLNFNESGAGLS--DHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRK 183
            |||.....|.||:  |         .||.|.....:|...|.|..||  |..||.:||.:...|:
Zfish     3 SGLTLTADGDGLTIMD---------PEDKLSREKLIFYLTVPLSSII--IFTNLFIIIGIACNRQ 56

  Fly   184 LRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFL--------CDLWNSLDVY----F 236
            |....|||.:||.:||:...|..                ||:        .|..:.|.:|    |
Zfish    57 LHNTPNYFFLSLLVADLCTGITL----------------PFIPRMSLDRQLDFRHCLVMYIFPNF 105

  Fly   237 STASIL-HLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGW--YTTPQ 298
            ...|.| :|..:..:||..||.||.:......|...:.||..|:.|.|.:.||.| ||  :....
Zfish   106 LFLSFLFNLVMVHYERYLCIVSPLHHSQFWVHRCFPLALLTVWLPPLLYASLPAF-GWNNWIEAA 169

  Fly   299 HQQFVIQNPT----QCSFVVNK------YYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLM 353
            ..:.:..|.|    |.|...:|      |..|...:..:...|.:::...|.|           :
Zfish   170 SNKSLDSNETFWRSQTSHNASKEDEVCSYKQVFPKAFIYVEVCGLVLPAMLCI-----------V 223

  Fly   354 MRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHE-VEQEHTPTKDKHLIKMKREHKAARTLGIIM 417
            ...|..:.:.|..:|            ....||. |::..|..:::.|     ..:.|:.:..:.
Zfish   224 CMTGRVLWIARKQLQ------------DICKLHRAVDRLQTSDQEQQL-----NLRYAKCVAAVS 271

  Fly   418 GTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWI----GYFNSTLNPLIYAYFNRDFREAFRN 478
            .||::||:|:.::..:|:|..:..| .:..|.|:.|    |..:..:.|||....|:.:.|..|.
Zfish   272 LTFLVCWVPYIIYQLMSVTALQSGV-SLPSSSLYIIMSCTGIGSMAVIPLILGLANKQYTEPIRR 335

  Fly   479 TLLCLFCNWWKDRHLPLDIDI 499
            .:|.| .|.|:..|...||.|
Zfish   336 VMLKL-RNRWRGGHSDRDITI 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	52/202 (26%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	73/324 (23%)
gpbar1	XP_009303247.3	7tmA_GPBAR1	29..326	CDD:320571	80/344 (23%)
		TM helix 1	29..54	CDD:320571	10/26 (38%)
		TM helix 2	61..86	CDD:320571	10/40 (25%)
		TM helix 3	96..126	CDD:320571	8/29 (28%)
		TM helix 4	139..162	CDD:320571	8/23 (35%)
		TM helix 5	202..231	CDD:320571	4/39 (10%)
		TM helix 6	258..288	CDD:320571	7/34 (21%)
		TM helix 7	301..326	CDD:320571	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910