DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and adrb3b

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_021334880.1	Gene:	adrb3b / 792519	ZFINID:	ZDB-GENE-081022-154	Length:	417	Species:	Danio rerio

Alignment Length:	415	Identity:	137/415 - (33%)
Similarity:	209/415 - (50%)	Gaps:	64/415 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 MLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPF 224
            :.|:|...:.||||||:::.|...|...||.|::|:|.||:::..:......|:.|.|:|.....
Zfish    21 LALVIFLTVIGNLLVILAIARTPLLHTTTNVFIISMAFADLIMGCVVQPLGLSMVVAGKWVLGNP 85

  Fly   225 LCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPI 289
            :||||.||||:..||||..||.|:|:||.||.:||::.:.:.||....::...||..:|:||:||
Zfish    86 MCDLWTSLDVFCVTASIETLCAIAVERYIAITRPLEHQVLLGKRRAAYIVCTVWIVSSLVSFVPI 150

  Fly   290 FIGWYTTPQHQQFV--------IQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREAN 346
            .       .|....        ..|...|.|..|::||:.||.:||::|..:|:|.|..:|..||
Zfish   151 M-------NHNSRANYLAANDCYNNSECCDFHTNQHYAIFSSVVSFYVPLLVMVFLYGKVFAIAN 208

  Fly   347 RQEKQLMMRHGNAMLMHRPSM-QPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAA 410
            :|.|.:    |...|....|. :.|.|...||..|           ::....||::|   ||||.
Zfish   209 KQLKLI----GKDRLRFLSSCNEDSCEIPEGSARS-----------YSRRTTKHVVK---EHKAL 255

  Fly   411 RTLGIIMGTFILCWLPFFLWYTLSMTCEECQVP-DIVVSILFWIGYFNSTLNPLIYAYFNRDFRE 474
            :|||||||.|.|||||||::..:.....|  || .:|..:|.|:||.||.|||:||.: :.::|.
Zfish   256 KTLGIIMGIFSLCWLPFFIFNIIKSFNPE--VPTQLVFLLLNWLGYANSGLNPIIYCH-SPEYRN 317

  Fly   475 AFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQMVDNLXYR 539
            ||.|.|.|.     |.:|             ::|...:.:.:|:   |:......|..:|.:.::
Zfish   318 AFFNLLGCK-----KPKH-------------FNQTTVNKHLQSF---TSCIQSNSSVRMDCMGHK 361

  Fly   540 DEALLTPIAQQQQRLAAGGSRLGGQ 564
            |     |||:.....:...|.|.|:
Zfish   362 D-----PIARGGNTCSDMSSVLKGE 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	66/185 (36%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	113/304 (37%)
adrb3b	XP_021334880.1	7tmA_Beta_AR	25..319	CDD:320186	117/321 (36%)
		TM helix 2	49..76	CDD:320186	8/26 (31%)
		TM helix 3	87..117	CDD:320186	19/29 (66%)
		TM helix 4	131..149	CDD:320186	5/17 (29%)
		TM helix 5	177..209	CDD:320186	13/31 (42%)
		TM helix 6	249..279	CDD:320186	20/32 (63%)
		TM helix 7	288..313	CDD:320186	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107218
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920