DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and agtr2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001072452.1	Gene:	agtr2 / 779906	XenbaseID:	XB-GENE-922095	Length:	352	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	80/338 - (23%)
Similarity:	137/338 - (40%)	Gaps:	74/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTG-RWNFSPFL 225
            :|....|.||.||||.:.....|:.:...::|:||:|| :|.:..:.|..:....| .|.|...:
Frog    37 IIFTFGIIGNCLVIIVLCLQGDLKSVAKIYIVNLAVAD-LVFLATLPFWATYYALGYNWLFGKVM 100

  Fly   226 CDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPIS---MTKRVVGIMLLNTWISPALLSFL 287
            |.:.:||......|||..:.|:|||||.|:|    ||.|   .||....::.::.||. |:||.:
Frog   101 CKISSSLLCLNLFASIFFISCMSVDRYVAVV----YPFSSQRRTKYQACLVSISVWIL-AILSSV 160

  Fly   288 PIFIGWYTTPQHQQFVIQNPTQCSFVVNKY------YAVISSSISFWIPCTIMIFTYLAIFREAN 346
            |.|  ::....:...:..:.....|...||      .:::...:.|.:|.:::...||.|.....
Frog   161 PTF--YFRNAFYINRLGAHVCAMDFPKEKYSSWCVGMSLMKIFLGFCVPVSVIATCYLMIGIHLK 223

  Fly   347 RQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAAR 411
            |                  |..|                              :|.::...:..:
Frog   224 R------------------SKGP------------------------------VINIQNRDRVQK 240

  Fly   412 TLGIIMGTFILCWLPF----FLWYTLSM-TCEECQVPDIV---VSILFWIGYFNSTLNPLIYAYF 468
            .:..|:..|::||.||    ||...:.| ....|::...:   :.....:|:.||.:|||:|.:.
Frog   241 IVTAIVMAFLICWFPFHALTFLDALVRMDIISHCKIVTFIEKAMPFCICMGFSNSCINPLLYCFV 305

  Fly   469 NRDFREAFRNTLL 481
            ...|||.||:..|
Frog   306 GNQFREHFRHLFL 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	51/187 (27%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	71/312 (23%)
agtr2	NP_001072452.1	7tmA_AT2R	29..313	CDD:341341	77/331 (23%)
		TM helix 1	30..56	CDD:341341	8/18 (44%)
		TM helix 2	63..88	CDD:341341	7/25 (28%)
		TM helix 3	101..131	CDD:341341	13/29 (45%)
		TM helix 4	142..166	CDD:341341	7/26 (27%)
		TM helix 5	192..221	CDD:341341	5/28 (18%)
		TM helix 6	233..263	CDD:341341	7/29 (24%)
		TM helix 7	281..306	CDD:341341	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910