DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and CCR2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001116513.2	Gene:	CCR2 / 729230	HGNCID:	1603	Length:	374	Species:	Homo sapiens

Alignment Length:	391	Identity:	83/391 - (21%)
Similarity:	150/391 - (38%)	Gaps:	112/391 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 NFNESGAGLSDHHHHQQHNPDEDW------------LDNIVWVFKAFVMLLIIIAAICGNLLVII 176
            |.||||..::....:....|...:            |.::|::| .||          ||:||::
Human    12 NTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIF-GFV----------GNMLVVL 65

  Fly   177 SVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASI 241
            .::..:||:.:|:.::::||::|::..|....:..|  ....|.|...:|.|:..|........|
Human    66 ILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHS--AANEWVFGNAMCKLFTGLYHIGYFGGI 128

  Fly   242 LHLCCISVDRYYAIVKPLKYPISMTKRVV--GIML-LNTWISPALLSFLPIFIGWYTTPQHQQFV 303
            ..:..:::|||.|||..:   .::..|.|  |::. :.||: .|:.:.:|..|  :|..|.:..|
Human   129 FFIILLTIDRYLAIVHAV---FALKARTVTFGVVTSVITWL-VAVFASVPGII--FTKCQKEDSV 187

  Fly   304 IQNPTQCSFVV--------NKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAM 360
                    :|.        |.::.::.:.:...:|..||:..|
Human   188 --------YVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICY---------------------- 222

  Fly   361 LMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWL 425
                            ||..|||.....|              |:.|:|.|.:..||..:.|.|.
Human   223 ----------------SGILKTLLRCRNE--------------KKRHRAVRVIFTIMIVYFLFWT 257

  Fly   426 PFFL---------WYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLL 481
            |:.:         ::.|| .||.....|....:...:|..:..:||:|||:....||..|...|.
Human   258 PYNIVILLNTFQEFFGLS-NCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALG 321

  Fly   482 C 482
            |
Human   322 C 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	41/188 (22%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	64/314 (20%)
CCR2	NP_001116513.2	7tmA_CCR5_CCR2	43..316	CDD:320312	74/352 (21%)
		TM helix 1	43..70	CDD:320312	9/37 (24%)
		TM helix 2	77..102	CDD:320312	6/26 (23%)
		TM helix 3	113..143	CDD:320312	8/29 (28%)
		TM helix 4	155..177	CDD:320312	5/22 (23%)
		TM helix 5	199..228	CDD:320312	7/66 (11%)
		TM helix 6	236..266	CDD:320312	9/29 (31%)
		TM helix 7	284..309	CDD:320312	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910