DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and TRHR

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_003292.1	Gene:	TRHR / 7201	HGNCID:	12299	Length:	398	Species:	Homo sapiens

Alignment Length:	410	Identity:	91/410 - (22%)
Similarity:	162/410 - (39%)	Gaps:	98/410 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIA--AICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNF 221
            ::|::||.  .|.||::|::.|||.:.:|..||.::||||:||:||.:.|...|.:..:.|.|.:
Human    29 ILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVY 93

  Fly   222 SPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSF 286
            ....|.....|......||...:...:::||.||..|:|.....|......:::..|...:|...
Human    94 GYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCM 158

  Fly   287 LPIFIGWYTTPQHQQFVIQNPTQCSFVVNK-YYA---VISSSISFWIPCTIMIFTYLAIFR---- 343
            |..|:.......::..::   ..|.:.::: ||:   ::...:.:.:|..:....|..|.|
Human   159 LWFFLLDLNISTYKDAIV---ISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFL 220

  Fly   344 -------EANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI 401
                   :.|.:..:....|.|..|    ::..|....:.:.||:                |.:.
Human   221 NPIPSDPKENSKTWKNDSTHQNTNL----NVNTSNRCFNSTVSSR----------------KQVT 265

  Fly   402 KMKREHKAARTLGIIMGTFILCWLPF--------FL-------WYTLSMTCEECQVPDIVVSILF 451
            ||         |.:::..|.|.|:|:        ||       |:.|  .|..|.
Human   266 KM---------LAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLL--FCRICI---------- 309

  Fly   452 WIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNW-WKDRHLPLDIDIRRSSLRYDQRAKS--- 512
               |.||.:||:||...::.||.|||.     .||. .|....|.:..:   :|.|....:|
Human   310 ---YLNSAINPVIYNLMSQKFRAAFRK-----LCNCKQKPTEKPANYSV---ALNYSVIKESDHF 363

  Fly   513 -------VYSESYLNSTTPS 525
                   ..:::||::|..|
Human   364 STELDDITVTDTYLSATKVS 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	44/183 (24%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	69/324 (21%)
TRHR	NP_003292.1	7tmA_TRH-R	26..331	CDD:320126	77/348 (22%)
		TM helix 1	27..53	CDD:320126	9/23 (39%)
		TM helix 2	60..85	CDD:320126	12/24 (50%)
		TM helix 3	98..128	CDD:320126	7/29 (24%)
		TM helix 4	141..162	CDD:320126	3/20 (15%)
		TM helix 5	188..217	CDD:320126	4/28 (14%)
		TM helix 6	259..289	CDD:320126	10/54 (19%)
		TM helix 7	299..324	CDD:320126	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910