DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Gpr21

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001103024.1	Gene:	Gpr21 / 689917	RGDID:	1586383	Length:	349	Species:	Rattus norvegicus

Alignment Length:	341	Identity:	81/341 - (23%)
Similarity:	144/341 - (42%)	Gaps:	52/341 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKL--RVITNYFVVSLAMADIMVAIMAMTFNFSVQVT 216
            :.:..:::.:.:..|.||::||. |.....|  ...|:||:.::|.||::|.:..:..:.|:...
  Rat    29 LLEVLIVVFLTVLIISGNIIVIF-VFHCAPLLNHHSTSYFIQTMAYADLLVGVSCLVPSLSLLYY 92

  Fly   217 GRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISP 281
            .........|.::..:.....:.|:..|.|||:|||.||.|||.|...:|...:.:.:...|:..
  Rat    93 PLPMEEAMTCQVFGFIVSVLKSISMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS 157

  Fly   282 ALLSFLPIFIGWYTTPQHQQFVIQNPTQC--SFVVNKYYAVISSSISFWIPCTIMI-FTYLAIFR 343
            .|: |||.|..|.....|....    ..|  |:..|.|:.:. ..::.:.|..::: |||..|||
  Rat   158 TLV-FLPSFFHWGKPGYHGDVF----RWCAESWHTNSYFTLF-IVMTLYAPAALIVCFTYFNIFR 216

  Fly   344 EANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHK 408
            ...:..|::..|..      |.|.| :||    :|.::|          .|.|           :
  Rat   217 ICQQHTKEISERQA------RFSSQ-NGE----TGEAQT----------CPDK-----------R 249

  Fly   409 AARTLGIIMGTFILCWLPFFLWYTL--SMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRD 471
            .|..|..|...|.:.|||:.:::.|  |..|..    .:...:..|:...||..|.:||:..|..
  Rat   250 YAMVLFRITSVFYVLWLPYIIYFLLESSTGCSS----RLASFLTTWLAISNSFCNCIIYSLSNSV 310

  Fly   472 FREAFR--NTLLCLFC 485
            |::..:  :..:|..|
  Rat   311 FQQGLKGLSESVCTSC 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	47/182 (26%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	74/301 (25%)
Gpr21	NP_001103024.1	7tm_classA_rhodopsin-like	31..308	CDD:410626	77/319 (24%)
		TM helix 1	31..55	CDD:410626	6/24 (25%)
		TM helix 2	65..87	CDD:410626	6/21 (29%)
		TM helix 3	103..125	CDD:410626	4/21 (19%)
		TM helix 4	148..164	CDD:410626	4/16 (25%)
		TM helix 5	189..212	CDD:410626	4/23 (17%)
		TM helix 6	251..273	CDD:410626	7/21 (33%)
		TM helix 7	283..308	CDD:410626	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910