DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and NPFFR1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_071429.1	Gene:	NPFFR1 / 64106	HGNCID:	17425	Length:	430	Species:	Homo sapiens

Alignment Length:	440	Identity:	96/440 - (21%)
Similarity:	170/440 - (38%)	Gaps:	102/440 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NATQPFGGSGLNFNESGA-GLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAIC--GNLLV 174
            |::.|...:|.|...:.| .|:...::|..:|          |...|::...:|..:|  ||.||
Human    10 NSSWPLSQNGTNTEATPATNLTFSSYYQHTSP----------VAAMFIVAYALIFLLCMVGNTLV 64

  Fly   175 IISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTA 239
            ...|::.|.:..:||.|:::||::|::|.|..|.......:...|.|....|.:...:.....:|
Human    65 CFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSA 129

  Fly   240 SILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVI 304
            |:..|..|:|:|:..||.|.:..:::.|.:|.|.::  | :.|||...|..:....|.:...|::
Human   130 SVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVI--W-ALALLIMCPSAVTLTVTREEHHFMV 191

  Fly   305 --QNPTQCSFV---------VNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGN 358
              :|.:...:.         :.:.|..:..|..:..|..:::..|..|.|:
Human   192 DARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARK-------------- 242

  Fly   359 AMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILC 423
              |...|...|.||..:...:|                       :|..:....|.::...|.|.
Human   243 --LCQAPGPAPGGEEAADPRAS-----------------------RRRARVVHMLVMVALFFTLS 282

  Fly   424 WLPFFLW-YTLSMTCEECQVPDIVVSILF------WIGYFNSTLNPLIYAYFNRDFREAFRNTLL 481
            |||  || ..|.:...:...|.:.:..::      |:.:|||:.||:||.|||.:||..|:....
Human   283 WLP--LWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFR 345

  Fly   482 CLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPS---HRR 528
            ...|                      .|....:.|:|  |..|.   |||
Human   346 ARLC----------------------PRPSGSHKEAY--SERPGGLLHRR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	44/190 (23%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	67/312 (21%)
NPFFR1	NP_071429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		2/9 (22%)
		7tm_GPCRs	44..340	CDD:333717	77/339 (23%)
		TM helix 1	46..70	CDD:320095	8/23 (35%)
		TM helix 2	79..101	CDD:320095	8/21 (38%)
		TM helix 3	117..139	CDD:320095	4/21 (19%)
		TM helix 4	160..176	CDD:320095	6/18 (33%)
		TM helix 5	214..237	CDD:320095	3/22 (14%)
		TM helix 6	266..291	CDD:320095	8/26 (31%)
		TM helix 7	308..333	CDD:320095	9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910