DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and PTGDR

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_000944.1	Gene:	PTGDR / 5729	HGNCID:	9591	Length:	359	Species:	Homo sapiens

Alignment Length:	375	Identity:	79/375 - (21%)
Similarity:	140/375 - (37%)	Gaps:	104/375 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIIIAAICGNLLVIISVMRV-------RKLRVITNYF---VVSLAMADIM-------VAIMAMTF 209
            ::....:.||||.:..:.|.       |.||.:.:.|   |..|.:.|::       |.:.|...
Human    25 VLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQ 89

  Fly   210 NFSVQVTGRWNFSP----FLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVV 270
            |.|::|     .:|    .||..:.....:|..:|.|.|..::::.:.::..|..|...:|.|
Human    90 NRSLRV-----LAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLR-- 147

  Fly   271 GIMLLNTWISPALLSF------LPIFIGWYTTPQHQQFVIQNP-TQC---------SFVVNKYYA 319
                |...::|.:.:|      || |:|:      .:||...| |.|         |..|..|..
Human   148 ----LGALVAPVVSAFSLAFCALP-FMGF------GKFVQYCPGTWCFIQMVHEEGSLSVLGYSV 201

  Fly   320 VISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLT 384
            :.||.::..:..|::  ..|...|......::| .||..:..  |...:|..:....|..    .
Human   202 LYSSLMALLVLATVL--CNLGAMRNLYAMHRRL-QRHPRSCT--RDCAEPRADGREASPQ----P 257

  Fly   385 LHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLP--FFLWY-------TLSMTCEEC 440
            |.|::         ||:          .|.::...|.:|.||  :..:|       ..:.|.||.
Human   258 LEELD---------HLL----------LLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEA 303

  Fly   441 QVPDI-------VVSILF-WIGYFNSTLNPLIYAYFNRDFREAFRNTLLC 482
            :  |:       |:||:. ||  |....:|:...:|::.|....|....|
Human   304 E--DLRALRFLSVISIVDPWI--FIIFRSPVFRIFFHKIFIRPLRYRSRC 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	47/214 (22%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	75/348 (22%)
PTGDR	NP_000944.1	7tmA_PGD2	17..335	CDD:320268	75/359 (21%)
		TM helix 1	18..44	CDD:320268	4/18 (22%)
		TM helix 2	61..87	CDD:320268	5/25 (20%)
		TM helix 3	105..135	CDD:320268	5/29 (17%)
		TM helix 4	147..169	CDD:320268	6/28 (21%)
		TM helix 5	195..224	CDD:320268	6/30 (20%)
		TM helix 6	258..288	CDD:320268	9/48 (19%)
		TM helix 7	302..327	CDD:320268	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910