DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and lpar2b

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001307062.1	Gene:	lpar2b / 567956	ZFINID:	ZDB-GENE-051120-99	Length:	369	Species:	Danio rerio

Alignment Length:	439	Identity:	98/439 - (22%)
Similarity:	182/439 - (41%)	Gaps:	103/439 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 WVFKAFVM----LLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSV 213
            |..||..:    ||:.:..|..|:||:.::...|:......|.:.:||.||:......|...|.
Zfish    24 WGTKAKAVVGMGLLVSVFVIFTNILVMAAIFMNRRFHYPIYYLLGNLAAADLFAGTSYMYLMFH- 87

  Fly   214 QVTGRWNFSPFLCDLW----NSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIML 274
              ||.|. :......|    ..:|... |||:.:|..|:::|:..|. .::....||...|.:::
Zfish    88 --TGPWT-AKLTTYQWFVRQGLIDTSL-TASVFNLMAIALERHQTIF-TMQLHSKMTNHRVVLLI 147

  Fly   275 LNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYL 339
            |..|....::..:|. :||     :....|.|.:..:.:.::.|.|..::|:. :..|:|:..|.
Zfish   148 LGIWTVAIIMGLVPA-MGW-----NCMCDIGNCSTMAPLYSRSYLVFWAAINL-LTFTVMVAVYT 205

  Fly   340 AIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMK 404
            .||....|:                               |:.::.|..:.:|..|    ::.:
Zfish   206 RIFIYVRRK-------------------------------SQRMSQHTSQVKHKET----VVNL- 234

  Fly   405 REHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFW--IGYFNSTLNPLIYAY 467
                 .:|:.:|:|.|::||.|..:...|...|..|   |::....|:  :...||.:||:||:|
Zfish   235 -----MKTVVMILGCFVVCWTPGMVLLLLDGLCHSC---DVLTYEKFFLVLAESNSLMNPIIYSY 291

  Fly   468 FNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSVYSESYLNSTTPSHRRQSQM 532
            .::|.|:.|:. :|||.|   :.:.......:|.::|..::| :.|..||||      .||.
Zfish   292 RDKDMRDTFKR-ILCLCC---RSKQSEEHSGVRFNTLEQERR-RRVQQESYL------ARRA--- 342

  Fly   533 VDNLXYRDEALLTPIAQQQQRLAAGGSRLGGQLAAAAKDGRESKDAKDT 581
                  ||..     |||:.         ||:|  ..::.:|..::.|:
Zfish   343 ------RDAG-----AQQEN---------GGRL--VLQENKEMLESSDS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	40/181 (22%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	62/300 (21%)
lpar2b	NP_001307062.1	7tmA_LPAR2_Edg4	29..300	CDD:320464	70/327 (21%)
		TM helix 1	30..56	CDD:320464	6/25 (24%)
		TM helix 2	63..88	CDD:320464	7/27 (26%)
		TM helix 3	100..130	CDD:320464	8/30 (27%)
		TM helix 4	143..161	CDD:320464	3/17 (18%)
		TM helix 5	181..210	CDD:320464	8/29 (28%)
		TM helix 6	229..259	CDD:320464	8/39 (21%)
		TM helix 7	268..293	CDD:320464	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910