DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and htr7a

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_021323081.1	Gene:	htr7a / 562111	ZFINID:	ZDB-GENE-130530-666	Length:	479	Species:	Danio rerio

Alignment Length:	359	Identity:	131/359 - (36%)
Similarity:	192/359 - (53%)	Gaps:	46/359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVT----GRW 219
            |:.::.:..||||:||:|||..|:|||..:||.:||||:||:.||:..|.|   |.:|    |||
Zfish   110 VLTMLTLITICGNMLVVISVCFVKKLRQPSNYLIVSLALADLSVALAVMPF---VSITDLIGGRW 171

  Fly   220 NFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALL 284
            .|..|.|:::.::||...||||:.||.||:|||..|.:||.||:......:..|:|:.|:..|.:
Zfish   172 IFGKFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGWCMAKMVLSVWLLSASI 236

  Fly   285 SFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQE 349
            :..|:| ||...       :.:...|....:..|.:.|::::|:||.|:|:..|..|||.|
Zfish   237 TLPPLF-GWAQN-------VNDDRVCLISQDFGYTIYSTAVAFYIPMTVMLVMYYRIFRAA---- 289

  Fly   350 KQLMMRH---GNAMLMHRPSMQPSGEALSGSGSSK-------TLTL---HEVEQ-EHTP------ 394
            |....:|   |...:......:...|...|:|:.:       |:.:   .|||: ...|
Zfish   290 KLSAAKHTITGFPRVEQEEVEEDEVEEDGGNGAEEPTGVDCVTVAIKLQREVEECARLPRILRGV 354

  Fly   395 ---TKDKHLIKM-KREHKAARTLGIIMGTFILCWLPFFLWYTL-SMTC-EECQ-VPDIVVSILFW 452
               ..|:..|.: |||.|||.||||::|.|.:|||||||..|. ...| .||. :|..|...|.|
Zfish   355 GRRCSDRRSISIFKREQKAAATLGIVVGAFTICWLPFFLLSTARPFICGTECSCIPLWVERTLLW 419

  Fly   453 IGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCN 486
            :||.||.:||.|||:||||.|..:|:.|.|.:.|
Zfish   420 LGYANSLINPFIYAFFNRDLRTTYRSLLSCRYRN 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	68/181 (38%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	116/325 (36%)
htr7a	XP_021323081.1	7tmA_5-HT7	105..443	CDD:320452	127/347 (37%)
		TM helix 1	106..132	CDD:320452	10/21 (48%)
		TM helix 2	139..165	CDD:320452	13/28 (46%)
		TM helix 3	178..208	CDD:320452	14/29 (48%)
		TM helix 4	220..242	CDD:320452	5/21 (24%)
		TM helix 5	259..288	CDD:320452	10/28 (36%)
		TM helix 6	368..398	CDD:320452	20/29 (69%)
		TM helix 7	411..436	CDD:320452	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910