DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Gpr62

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001153124.1	Gene:	Gpr62 / 436090	MGIID:	3525078	Length:	358	Species:	Mus musculus

Alignment Length:	365	Identity:	75/365 - (20%)
Similarity:	132/365 - (36%)	Gaps:	81/365 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVM-LLIIIAAICGNLLVIISVMRVRK 183
            ||||:..|....:                        .|:: :|:.:.|:.||..:::.|:|...
Mouse     4 GSGLSVTELAGSV------------------------GFILAVLVEVGAVLGNGTLLVVVLRTPD 44

  Fly   184 LRVITNYFVVSLAMADIMVA--IMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCC 246
            |:  ..:::..|.:.|::.|  ||.:....:....|.....|..|.....|......|..|.:..
Mouse    45 LQ--DAFYLAHLCVVDLLAAASIMPLGLLAAPPGLGTVPLDPSSCRAARFLSAALLPACTLGVAA 107

  Fly   247 ISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNPTQCS 311
            :.:.||..||.||:   ...:....::|...|.:.|||..|.: :|....|.      ..|.:||
Mouse   108 LGLARYRLIVHPLR---PGARPAPALVLTAVWSAAALLGALSL-LGPPPAPP------PAPARCS 162

  Fly   312 FVVNKY--YAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEAL 374
            .:....  :..:.:.::|.:|..:::..|.:||..|.|           |.|......:|..::|
Mouse   163 VLAGGLGPFRPLWAMLAFALPALLLLAAYGSIFLVARR-----------AALRPPRGTRPRSDSL 216

  Fly   375 SGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEE 439
                .|:...|       .|.:.:.|     ..|||....:.:|.|..||||:        .| .
Mouse   217 ----DSRLSFL-------PPLRPRLL-----GGKAALAPALAVGQFAACWLPY--------GC-A 256

  Fly   440 CQVP----DIVVSILFWIGYFNSTLNPLIYAYFNRDFREA 475
            |..|    ....:.:.|:.|.....:|.:|....|..|.|
Mouse   257 CLAPAARAAAAEATVTWVAYSAFAAHPFLYGLLQRPVRLA 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	37/181 (20%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	63/302 (21%)
Gpr62	NP_001153124.1	7tm_GPCRs	16..297	CDD:391938	70/353 (20%)
		TM helix 1	17..41	CDD:341315	6/23 (26%)
		TM helix 2	48..70	CDD:341315	5/21 (24%)
		TM helix 3	88..110	CDD:341315	3/21 (14%)
		TM helix 4	130..145	CDD:341315	5/14 (36%)
		TM helix 5	169..192	CDD:341315	2/22 (9%)
		TM helix 6	233..255	CDD:341315	9/29 (31%)
		TM helix 7	265..290	CDD:341315	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910