Protein Alignment Octbeta2R and Hcrtr2

DIOPT Version :9

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_945200.1
• Gene: Hcrtr2 / 387285
• MGIID: 2680765
• Length: 460
• Species: Mus musculus
• Alignment Length: 505
• Identity: 127/505 - (25%)
• Similarity: 197/505 - (39%)
• Gaps: 144/505 - (28%)

  Fly   111 ELNATQ-PFGGSGLNFNESGAGLSDHHHHQQHNP----DEDWL----------DNIVWVFKAFVM 160
            |||.|| ||                      .||    ||::|          ....||..|..:
Mouse    20 ELNETQEPF----------------------LNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYI 62

  Fly   161 LLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFL 225
            ::.::|.| ||:||.::|.:...:|.:||||:|:|::||::|.|..:.....|.:|..|.|...|
Mouse    63 IVFVVALI-GNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSL 126

  Fly   226 CDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALL------ 284
            |.:...|.....:.|:|.|.||::||:|||..||.:. |..||....::: .||...::
Mouse   127 CKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFK-STAKRARNSIVV-IWIVSCIIMIPQAI 189

  Fly   285 -----SFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFRE 344
                 |.||......|.     |.:.:......|..|.|.:....:::..|..:||..||.|||
Mouse   190 VMECSSMLPGLANKTTL-----FTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFR- 248

  Fly   345 ANRQEKQLMMRH--GNAMLMHR------PSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI 401
                  :|..|.  |.:.::.|      |..||     .|||......:..|..|        :.
Mouse   249 ------KLWCRQIPGTSSVVQRKWKQQQPVSQP-----RGSGQQSKARISAVAAE--------IK 294

  Fly   402 KMKREHKAARTLGIIMGTFILCWLPF----------------------FLWYTLSMTCEECQVPD 444
            :::...|.||.|.:::..|.:|:||.                      :.|:|.|
Mouse   295 QIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFS---------- 349

  Fly   445 IVVSILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQR 509
                  .|:.|.||..||:||.:.:..|||.|:....|  |         |.:..|:.    |:.
Mouse   350 ------HWLVYANSAANPIIYNFLSGKFREEFKAAFSC--C---------LGVHHRQG----DRL 393

  Fly   510 AKS-VYSESYLNSTTPSHRRQSQMVDNLXYRDE-ALLTPIAQQQQRLAAG 557
            |:. ..:||..:.||     |....||: ...| .:||.|:.......||
Mouse   394 ARGRTSTESRKSLTT-----QISNFDNVSKLSEHVVLTSISTLPAANGAG 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	55/188 (29%)
		7tm_1	170..465	CDD:278431	85/335 (25%)
Hcrtr2	NP_945200.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		3/15 (20%)
		7tm_4	65..>194	CDD:304433	42/131 (32%)
		7tm_1	71..364	CDD:278431	85/335 (25%)
		Orexin_rec2	386..443	CDD:281778	16/62 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910