Protein Alignment Octbeta2R and HTR4

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001035263.1
• Gene: HTR4 / 3360
• HGNCID: 5299
• Length: 428
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 139/367 - (37%)
• Similarity: 188/367 - (51%)
• Gaps: 68/367 - (18%)

  Fly   159 VMLL-----IIIAAICGNLLVIISVMRVRKLRVI-TNYFVVSLAMADIMVAIMAMTFNFSVQVTG 217
            |:||     :|:.||.|||||:::|...|:||.| ||||:||||.||::|:::.|.|.....|..
Human    20 VVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQD 84

  Fly   218 RWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAI-VKPLKYPISMTKRVVGIMLLNTWISP 281
            .|.:....|.:..||||..:||||.||||||:|||||| .:||.|...||...:.:||...|:.|
Human    85 IWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIP 149

  Fly   282 ALLSFLPIFIGWYTTP-----QHQQF-VIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLA 340
            ..:|||||..||....     :.::| ...|.|.|.|:|||.||:..|.::|:||..:|:..|..
Human   150 TFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYR 214

  Fly   341 IFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKR 405
            |:..|.....|:.|                   |..:|:|........:|..|     |  :|:.
Human   215 IYVTAKEHAHQIQM-------------------LQRAGASSESRPQSADQHST-----H--RMRT 253

  Fly   406 EHKAARTLGIIMGTFILCWLPFFLW--------YTLSMTCEECQVPDIVVSILFWIGYFNSTLNP 462
            |.|||:||.||||.|.|||.|||:.        ||         ||..|.:...|:||.||.|||
Human   254 ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYT---------VPGQVWTAFLWLGYINSGLNP 309

  Fly   463 LIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSL 504
            .:||:.|:.||.||   |:.|.|:         |...||.|:
Human   310 FLYAFLNKSFRRAF---LIILCCD---------DERYRRPSI 339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	130/337 (39%)
		TM helix 1	155..181	CDD:320194	12/26 (46%)
		TM helix 2	188..214	CDD:320194	13/25 (52%)
		TM helix 3	226..256	CDD:320194	21/30 (70%)
		TM helix 4	268..291	CDD:320194	9/22 (41%)
		TM helix 5	315..344	CDD:320194	11/28 (39%)
		TM helix 6	404..434	CDD:320194	19/37 (51%)
		TM helix 7	444..469	CDD:320194	11/24 (46%)
HTR4	NP_001035263.1	7tmA_5-HT4	20..323	CDD:320184	130/337 (39%)
		TM helix 1	21..47	CDD:320184	11/25 (44%)
		TM helix 2	55..81	CDD:320184	13/25 (52%)
		TM helix 3	93..123	CDD:320184	20/29 (69%)
		TM helix 4	136..159	CDD:320184	9/22 (41%)
		TM helix 5	189..218	CDD:320184	11/28 (39%)
		TM helix 6	252..282	CDD:320184	17/29 (59%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)