Protein Alignment Octbeta2R and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_061501849.1
• Gene: Octalpha2R / 3289716
• VectorBaseID: AGAMI1_006243
• Length: 636
• Species: Anopheles gambiae
• Alignment Length: 660
• Identity: 149/660 - (22%)
• Similarity: 229/660 - (34%)
• Gaps: 274/660 - (41%)

  Fly    46 GGIVSNPISYGQSLTTLARVTAAALTTAAMLHTTNALAATGSSSASNSSTGGIALPLGTATPATH 110
            |.:...|..:..||...|...|||...|                      ||:|.|.|||
Mosquito    24 GTVGGGPTMFNDSLAVAAAAAAAAAAAA----------------------GGVAGPGGTA----- 61

  Fly   111 ELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVI 175
                    .|.|     .|..|:..|...   |....|.:|  :..:.::.:::|..:.||:|||
Mosquito    62 --------AGVG-----PGENLTILHGAY---PSGYTLPHI--IIASIIVTILMIVIVVGNMLVI 108

  Fly   176 ISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTAS 240
            |::...:.|:.|.|:|:.|||:||..:.::.|.|:.:.::.|.|.|..:.||:.:::||...|:|
Mosquito   109 IAIATEKTLKNIQNWFIASLAVADFFLGLVIMPFSLANELMGYWIFGNWWCDVHSAMDVLLCTSS 173

  Fly   241 ILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQ 305
            |::||.||:|||::|.|.::|..|.|......|:...||..||:. :|..:||  ..|..:..::
Mosquito   174 IMNLCLISLDRYWSITKAIEYLKSRTPARAAFMIAAVWIMSALVC-IPPLLGW--KAQRPEGHVE 235

  Fly   306 NPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIF---------------------------- 342
            .| ||....:..|.:.|:..||:||..||:|.|:.|:
Mosquito   236 LP-QCQLSQDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIRKKPLKPPSEQDTSFTR 299

  Fly   343 ----------------------REANRQEKQLMM------------------------------- 354
                                  ..|:.|:..:.:
Mosquito   300 NAGTVPMPSLPSASSNNNQSAAAAAHHQQHPVQLSSGAQGGGSTQIATIEPPPRGTPMPIPVVTC 364

  Fly   355 -----------------RHG----------NAMLMHRPSMQ------------------------ 368
                             :||          :.:.:.:|:.|
Mosquito   365 DFASDMSTSEAATAEQDQHGPISPVALEPKDTLKVTQPAQQGRSTNGITAAGAATEPVASPSSAA 429

  Fly   369 -------------------PS------------------------------------------GE 372
                               ||                                          |.
Mosquito   430 ARSRALSVGIDTDMVSEFDPSSSDSGVISRCAVVKPLKFRLCQPIFGKGKAKARQANAKAAGHGG 494

  Fly   373 ALSGSGSSKTLT-------------------------LHEVE-------QEHTPTKDKHLIKMKR 405
            |.:|.|::...|                         ..|:|       :...|.|:|..|..|:
Mosquito   495 AHAGRGNAPNCTQPMLAAPGGQQAISQLIAAKQTDSACSELEPALPPKPKPRDPEKEKRRIARKK 559

  Fly   406 EHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNR 470
            |.:|...||:|||:||.||||||..|.|...|.:|.:||...|:.||:||.||.|||.||..||:
Mosquito   560 EKRATLILGLIMGSFIACWLPFFFLYILVPVCPDCHIPDSAFSLAFWLGYMNSALNPAIYTIFNK 624

  Fly   471 DFREAFRNTL 480
            |||.|||..|
Mosquito   625 DFRRAFRRIL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	121/545 (22%)
		TM helix 1	155..181	CDD:320194	7/25 (28%)
		TM helix 2	188..214	CDD:320194	9/25 (36%)
		TM helix 3	226..256	CDD:320194	14/29 (48%)
		TM helix 4	268..291	CDD:320194	6/22 (27%)
		TM helix 5	315..344	CDD:320194	11/78 (14%)
		TM helix 6	404..434	CDD:320194	17/29 (59%)
		TM helix 7	444..469	CDD:320194	13/24 (54%)
Octalpha2R	XP_061501849.1	None