DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Gpr61

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001101185.2	Gene:	Gpr61 / 310780	RGDID:	1310176	Length:	449	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	121/470 - (25%)
Similarity:	186/470 - (39%)	Gaps:	104/470 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 SASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVW 153
            |:.||||.|.||    .||.        |...||:                   |:....|....
  Rat     9 SSGNSSTLGRAL----QTPG--------PSTASGV-------------------PELGLRDVASE 42

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVA--IMAMTFNFSVQVT 216
            ....|.|||:.:.|:.||..|:..:.:...||...  ||..|.:.|::.|  :|.:....|..:.
  Rat    43 SVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALF 105

  Fly   217 GRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISP 281
            ....|....|.|:..|.|.|.:.:||.:..|:|:|||.:|.|::|.:.||..:|..:|:..|:..
  Rat   106 DHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKA 170

  Fly   282 ALLSFLPIF--IGWYTTPQHQQFVIQNPTQCSF-----VVNKYYAVISSSISFWIPCTIMIFTYL 339
            ..::.:|:.  :.|     .:.....|| .||.     ...:.:.|:.:.:.|.:|..::...|.
  Rat   171 LAMASVPVLGRVYW-----EEGAPSVNP-GCSLQWSHSAYCQLFVVVFAVLYFLLPLILIFVVYC 229

  Fly   340 AIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMK 404
            ::||.|    :...|:||..........|.| |:||   |..|:.......:.||
  Rat   230 SMFRVA----RVAAMQHGPLPTWMETPRQRS-ESLS---SRSTMVTSSGAHQTTP---------- 276

  Fly   405 REH------KAARTLGIIMGTFILCWLPFF---LWYTLS-MTCEECQVPDIVVSILFWIGYFNST 459
              |      |||..|..:.|.|:|||||:|   |:..|| ......||.::|.    |||||..|
  Rat   277 --HRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVENVVT----WIGYFCFT 335

  Fly   460 LNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSV----------Y 514
            .||..|...||..|.......:|.|      :..|      ...||...|..|:          .
  Rat   336 SNPFFYGCLNRQIRGELSKQFVCFF------KAAP------EEELRLPSREGSIEENFLQFLQGT 388

  Fly   515 SESYLNSTTPSHRRQ 529
            ||::::...||.:|:
  Rat   389 SENWVSRPLPSPKRE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	44/186 (24%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	85/313 (27%)
Gpr61	NP_001101185.2	7tmA_GPR61_GPR62-like	44..352	CDD:410633	94/339 (28%)
		TM helix 1	45..69	CDD:410633	8/23 (35%)
		TM helix 2	76..98	CDD:410633	6/23 (26%)
		TM helix 3	116..138	CDD:410633	7/21 (33%)
		TM helix 4	161..177	CDD:410633	2/15 (13%)
		TM helix 5	206..229	CDD:410633	3/22 (14%)
		TM helix 6	286..308	CDD:410633	10/21 (48%)
		TM helix 7	320..345	CDD:410633	12/28 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910