DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Gpr63

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001100110.1	Gene:	Gpr63 / 297952	RGDID:	1306460	Length:	425	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	114/457 - (24%)
Similarity:	185/457 - (40%)	Gaps:	107/457 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VTAAALTTAAMLHTTNALAATGSSSAS----NSSTGGIALPLGTATPA-----THELNATQPFGG 120
            |.:..||..|:|.|.:    ||:|:.:    .:|...|..||....|:     .:.|......|.
  Rat     2 VVSGVLTAPAVLTTPH----TGTSNMTFVVYENSPMNITAPLPFQHPSPGPLLRYSLETMTSTGF 62

  Fly   121 SGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVW----VFKAF----------VMLLIIIAAICGN 171
            |.|..|.:                      :|.    |||:.          :|:.|:..:..||
  Rat    63 SSLAVNST----------------------VVTPAPAVFKSLNLALQIILSAIMIFILFVSFLGN 105

  Fly   172 LLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYF 236
            |:|.:.|.:...:|...|..:.|:|.||:::|::.|.|.....:|.||.|..|.|.|.......|
  Rat   106 LVVCLMVYQKAAMRSAINILLASMAFADMLLAVLNMPFALVTILTTRWIFGKFFCRLSAMFFWLF 170

  Fly   237 STASILHLCCISVDRYYAIVK------PLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYT 295
            ....:..|..||:||:..||:      |.:         ..:::..:|.:...::| |:.:|
  Rat   171 VIEGVAILLIISIDRFLIIVQRQDKLNPYR---------AKVLIAVSWATAFSVAF-PLAVG--- 222

  Fly   296 TPQHQQFVIQNPTQCSF--VVN---KYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQLMMR 355
            .|..|  :.....||.|  ..|   :.|.::.|.|||:||..:::::::.|..         .:|
  Rat   223 NPDLQ--IPSRAPQCVFGYTTNSGYQAYVILISLISFFIPFLVILYSFMGILN---------TLR 276

  Fly   356 HGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAARTLGIIMGTF 420
            | ||:.:|   ..|.|..||.......::|....|..        |.|..:.:|..|:.|:...|
  Rat   277 H-NALRIH---SYPEGICLSQVSKLGLMSLQRPFQMS--------IDMSFKTRAFTTILILFAVF 329

  Fly   421 ILCWLPFFLWYTLSMTCEE---CQVPDIVVSI-LFWIGYFNSTLNPLIYAYFNRDFREAFRNTLL 481
            |:||.| |..|:|..|..:   .|.....:|. |.|:.|..|.||||||.:..:.|.:|
  Rat   330 IVCWAP-FTTYSLVATFSKHFYYQHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFHDA------ 387

  Fly   482 CL 483
            ||
  Rat   388 CL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	47/188 (25%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	83/309 (27%)
Gpr63	NP_001100110.1	7tmA_GPR63	88..388	CDD:320526	89/342 (26%)
		TM helix 1	90..114	CDD:320526	7/23 (30%)
		TM helix 2	123..145	CDD:320526	8/21 (38%)
		TM helix 3	161..183	CDD:320526	4/21 (19%)
		TM helix 4	203..219	CDD:320526	2/16 (13%)
		TM helix 5	246..269	CDD:320526	7/22 (32%)
		TM helix 6	319..341	CDD:320526	9/22 (41%)
		TM helix 7	356..381	CDD:320526	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910