DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and GPR78

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_543009.2	Gene:	GPR78 / 27201	HGNCID:	4528	Length:	363	Species:	Homo sapiens

Alignment Length:	339	Identity:	70/339 - (20%)
Similarity:	141/339 - (41%)	Gaps:	65/339 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 AFVMLLIIIAAICGNLLVIISVMRVRKLRV-ITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWN 220
            |.::::::..|:..|.||::......:||. .:...:|:|::..:::|.:.|.|.....:.||..
Human     9 AGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTP 73

  Fly   221 FSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLS 285
            .:|..|.:...||.:.::.:.|.:..:|.|::.|:..||:|...:..|..|::|...|......|
Human    74 SAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFS 138

  Fly   286 FLPIFIGW--YTT------------PQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIF 336
            ...:...|  |::            |:..:|..             :.....::.|.:|..::..
Human   139 GAALGCSWLGYSSAFASCSLRLPPEPERPRFAA-------------FTATLHAVGFVLPLAVLCL 190

  Fly   337 TYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI 401
            |.|.:.|.|.|..:::                       .:.:.|.|.|  :...|...:.:.||
Human   191 TSLQVHRVARRHCQRM-----------------------DTVTMKALAL--LADLHPSVRQRCLI 230

  Fly   402 KMK-REHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWI-----GYFNSTL 460
            :.| |.|:|.|.:||.:.||::|:.|    |.::...|  .||.:.|:..:.|     .|..:..
Human   231 QQKRRRHRATRKIGIAIATFLICFAP----YVMTRLAE--LVPFVTVNAQWGILSKCLTYSKAVA 289

  Fly   461 NPLIYAYFNRDFRE 474
            :|..|:...|.||:
Human   290 DPFTYSLLRRPFRQ 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	37/192 (19%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	64/315 (20%)
GPR78	NP_543009.2	7tm_1	23..294	CDD:278431	64/314 (20%)
GPR78	NP_543009.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..363
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910