DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and OXGR1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001333123.1	Gene:	OXGR1 / 27199	HGNCID:	4531	Length:	337	Species:	Homo sapiens

Alignment Length:	338	Identity:	72/338 - (21%)
Similarity:	137/338 - (40%)	Gaps:	77/338 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIIIAAICGNLLVIIS-VMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTG-RWNFSPF 224
            :|.:....||.:||.: :.::|..:..| ..:::||..|::. :.::.|......:| .|.|..|
Human    42 IIFLVGFPGNAVVISTYIFKMRPWKSST-IIMLNLACTDLLY-LTSLPFLIHYYASGENWIFGDF 104

  Fly   225 LCDLWNSLDVYFS-----TASILHLCCISVDRYYAIVKPLK-YPISMTKRVVGIMLLNTWISPAL 283
            :|..     :.||     .:|||.|.|.|:.||..|:.|:. :.|..|:..| :.....||. :|
Human   105 MCKF-----IRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAV-VACAVVWII-SL 162

  Fly   284 LSFLPI-FIGWYTTPQHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANR 347
            ::.:|: |:...|...::...:...:.......|:|.:|.::.:|.:|..|:...|..|..
Human   163 VAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIH---- 223

  Fly   348 QEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMKREHKAART 412
                                              |||       |....|..|     :.||.|.
Human   224 ----------------------------------TLT-------HGLQTDSCL-----KQKARRL 242

  Fly   413 LGIIMGTFILCWLPFFLWYT-------LSMTCE-ECQVPDIVVSILFWIGYFNSTLNPLIYAYFN 469
            ..:::..|.:|:|||.:...       ||::|. |.|:.:..: :...:...|:..|.|:|...:
Human   243 TILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYI-VSRPLAALNTFGNLLLYVVVS 306

  Fly   470 RDFREAFRNTLLC 482
            .:|::|..:|:.|
Human   307 DNFQQAVCSTVRC 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	43/186 (23%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	66/311 (21%)
OXGR1	NP_001333123.1	7tmA_OXGR1	34..313	CDD:320497	69/330 (21%)
		TM helix 1	34..61	CDD:320497	5/18 (28%)
		TM helix 2	68..93	CDD:320497	5/26 (19%)
		TM helix 3	106..136	CDD:320497	11/34 (32%)
		TM helix 4	148..170	CDD:320497	5/23 (22%)
		TM helix 5	195..224	CDD:320497	8/66 (12%)
		TM helix 6	234..264	CDD:320497	9/34 (26%)
		TM helix 7	281..306	CDD:320497	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910