DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Htr4

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_036985.2	Gene:	Htr4 / 25324	RGDID:	2850	Length:	388	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	130/343 - (37%)
Similarity:	176/343 - (51%)	Gaps:	63/343 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LIIIAAICGNLLVIISVMRVRKLRVI-TNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFL 225
            ::|:.||.|||||:::|.|.|:||.| ||||:||||.||::|:::.|.|.....|...|.:....
  Rat    28 MVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMF 92

  Fly   226 CDLWNSLDVYFSTASILHLCCISVDRYYAI-VKPLKYPISMTKRVVGIMLLNTWISPALLSFLPI 289
            |.:..||||..:||||.||||||:|||||| .:||.|...||...:.:||...|:.|..:|||||
  Rat    93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPI 157

  Fly   290 FIGWYTTP----------QHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFRE 344
            ..||....          .|.    .|.|.|.|:|||.||:..|.::|:||..:|:..|..|:..
  Rat   158 MQGWNNIGIVDVIEKRKFNHN----SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT 218

  Fly   345 ANRQEKQL-MMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI-KMKREH 407
            |....:|: |::...|....||.                            |.|:|.. :|:.|.
  Rat   219 AKEHAQQIQMLQRAGATSESRPQ----------------------------TADQHSTHRMRTET 255

  Fly   408 KAARTLGIIMGTFILCWLPFFLW--------YTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLI 464
            |||:||.:|||.|..||.|||:.        ||         ||:.|.:...|:||.||.|||.:
  Rat   256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT---------VPEKVWTAFLWLGYINSGLNPFL 311

  Fly   465 YAYFNRDFREAFRNTLLC 482
            ||:.|:.||.||...|.|
  Rat   312 YAFLNKSFRRAFLIILCC 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	82/189 (43%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	118/316 (37%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	126/335 (38%)
		TM helix 1	22..46	CDD:320184	9/17 (53%)
		TM helix 2	56..78	CDD:320184	12/21 (57%)
		TM helix 3	94..116	CDD:320184	13/21 (62%)
		TM helix 4	140..156	CDD:320184	6/15 (40%)
		TM helix 5	190..213	CDD:320184	8/22 (36%)
		TM helix 6	258..280	CDD:320184	12/21 (57%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	1	1.000	-	-		FOG0005484
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	1	0.900	-	-		OOG6_107218
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820