Protein Alignment Octbeta2R and Htr4

DIOPT Version :10

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_036985.2
• Gene: Htr4 / 25324
• RGDID: 2850
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 343
• Identity: 130/343 - (37%)
• Similarity: 176/343 - (51%)
• Gaps: 63/343 - (18%)

  Fly   162 LIIIAAICGNLLVIISVMRVRKLRVI-TNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFL 225
            ::|:.||.|||||:::|.|.|:||.| ||||:||||.||::|:::.|.|.....|...|.:....
  Rat    28 MVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWFYGEMF 92

  Fly   226 CDLWNSLDVYFSTASILHLCCISVDRYYAI-VKPLKYPISMTKRVVGIMLLNTWISPALLSFLPI 289
            |.:..||||..:||||.||||||:|||||| .:||.|...||...:.:||...|:.|..:|||||
  Rat    93 CLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPI 157

  Fly   290 FIGWYTTP----------QHQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFRE 344
            ..||....          .|.    .|.|.|.|:|||.||:..|.::|:||..:|:..|..|:..
  Rat   158 MQGWNNIGIVDVIEKRKFNHN----SNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVT 218

  Fly   345 ANRQEKQL-MMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI-KMKREH 407
            |....:|: |::...|....||.                            |.|:|.. :|:.|.
  Rat   219 AKEHAQQIQMLQRAGATSESRPQ----------------------------TADQHSTHRMRTET 255

  Fly   408 KAARTLGIIMGTFILCWLPFFLW--------YTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLI 464
            |||:||.:|||.|..||.|||:.        ||         ||:.|.:...|:||.||.|||.:
  Rat   256 KAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYT---------VPEKVWTAFLWLGYINSGLNPFL 311

  Fly   465 YAYFNRDFREAFRNTLLC 482
            ||:.|:.||.||...|.|
  Rat   312 YAFLNKSFRRAFLIILCC 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tmA_DmOct-betaAR-like	155..476	CDD:320194	126/335 (38%)
		TM helix 1	155..181	CDD:320194	9/18 (50%)
		TM helix 2	188..214	CDD:320194	13/25 (52%)
		TM helix 3	226..256	CDD:320194	21/30 (70%)
		TM helix 4	268..291	CDD:320194	9/22 (41%)
		TM helix 5	315..344	CDD:320194	11/28 (39%)
		TM helix 6	404..434	CDD:320194	17/37 (46%)
		TM helix 7	444..469	CDD:320194	11/24 (46%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	126/335 (38%)
		TM helix 1	21..47	CDD:320184	9/18 (50%)
		TM helix 2	55..81	CDD:320184	13/25 (52%)
		TM helix 3	93..123	CDD:320184	20/29 (69%)
		TM helix 4	136..159	CDD:320184	9/22 (41%)
		TM helix 5	189..218	CDD:320184	11/28 (39%)
		TM helix 6	252..282	CDD:320184	15/29 (52%)
		TM helix 7	291..316	CDD:320184	11/24 (46%)