DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and Drd5

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_036900.1	Gene:	Drd5 / 25195	RGDID:	2523	Length:	475	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	144/457 - (31%)
Similarity:	221/457 - (48%)	Gaps:	93/457 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRV-ITNYFVVSLAMADIMVAIMAMTFNFSVQVTG 217
            |..|.::.|:|:..:.||:||..:::|.|.||. :||.|:||||::|:.||::.|.:....:|.|
  Rat    39 VVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAG 103

  Fly   218 RWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPA 282
            .|.|..| ||:|.:.|:..||||||:||.||||||:||.:|.:|...||:||..:|:...|....
  Rat   104 YWPFGTF-CDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSI 167

  Fly   283 LLSFLPIFIGWYT---------------TPQHQQFVIQNPTQ-CSFVVNKYYAVISSSISFWIPC 331
            |:||:|:.:.|:.               ||..:.:.::..|: |...:|:.||:.||.|||:||.
  Rat   168 LISFIPVQLNWHRDKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPV 232

  Fly   332 TIMIFTYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTK 396
            .|||.||..|:|.|..|.:::            .|::.:.|   .:.|.::...:|        .
  Rat   233 AIMIVTYTRIYRIAQVQIRRI------------SSLERAAE---HAQSCRSRGAYE--------P 274

  Fly   397 DKHL-IKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEE-----------CQVPDIVVSI 449
            |..| ..:|:|.|..:||.:|||.|:.||||||:...:...|..           | |.:....|
  Rat   275 DPSLRASIKKETKVFKTLSMIMGVFVCCWLPFFILNCMVPFCSSGDAEGPKTGFPC-VSETTFDI 338

  Fly   450 LFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCL-FCNWWKDRHLPLD-IDIRRSSLRYDQRA-- 510
            ..|.|:.||:|||:||| ||.|||:.|...|.|. ||     ...|:. ::|....:.|:|..
  Rat   339 FVWFGWANSSLNPIIYA-FNADFRKVFAQLLGCSHFC-----FRTPVQTVNISNELISYNQDTVF 397

  Fly   511 --------------------KSVYSE---------SYLNSTTPSHRRQSQMVDNLXYRDEALLTP 546
                                :.|..|         |.::.|||.....::.|..| ..:|..|..
  Rat   398 HKEIATAYVHMIPNAVSSGDREVGEEEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGK 462

  Fly   547 IA 548
            |:
  Rat   463 IS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	77/194 (40%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	112/323 (35%)
Drd5	NP_036900.1	7tm_1	55..354	CDD:278431	112/323 (35%)
		7tm_4	<121..>173	CDD:304433	27/51 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..443		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970