DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Adrb1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_036833.1	Gene:	Adrb1 / 24925	RGDID:	2059	Length:	466	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	144/411 - (35%)
Similarity:	214/411 - (52%)	Gaps:	47/411 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ATGSSSASNSSTGGIALPLGTATPATHELNATQPFGGSGL-NFNESGAGLSDHHHHQQHNPDEDW 147
            |.|:|...|.|:.. .||.|.||.|...:.|:.|  .|.| ..:|..|.||           :.|
  Rat     7 ALGASEPCNLSSAA-PLPDGAATAARLLVLASPP--ASLLPPASEGSAPLS-----------QQW 57

  Fly   148 LDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFS 212
            ...:     ..::.||::..:.||:|||:::.:..:|:.:||.|::|||.||:::.::.:.|..:
  Rat    58 TAGM-----GLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGAT 117

  Fly   213 VQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNT 277
            :.|.|||.:..|.|:||.|:||...||||..||.|::|||.||..|.:|...:|:.....::...
  Rat   118 IVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTV 182

  Fly   278 WISPALLSFLPIFIGWYTTPQHQ-QFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAI 341
            |...||:|||||.:.|:.....: :....:|..|.||.|:.||:.||.:||::|..||.|.||.:
  Rat   183 WAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRV 247

  Fly   342 FREANRQEKQL--MMRHGNAMLMHRPSMQPS--------GEALSGSGSSKTLTLHEVEQEHTPTK 396
            ||||.:|.|::  ..|.........||..||        .::|:...|||             .:
  Rat   248 FREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSK-------------RR 299

  Fly   397 DKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLN 461
            ...|:.: ||.||.:|||||||.|.||||||||...:.....:. |||.:.....|:||.||..|
  Rat   300 PSRLVAL-REQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDL-VPDRLFVFFNWLGYANSAFN 362

  Fly   462 PLIYAYFNRDFREAFRNTLLC 482
            |:||.. :.|||:||:..|.|
  Rat   363 PIIYCR-SPDFRKAFQRLLCC 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	67/178 (38%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	113/305 (37%)
Adrb1	NP_036833.1	7tm_1	75..366	CDD:278431	113/305 (37%)
		7tm_4	76..>267	CDD:304433	73/190 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..302		8/50 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..466
		PDZ-Binding. /evidence=ECO:0000250	463..466
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020