DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and Gpr101

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001028532.1	Gene:	Gpr101 / 245424	MGIID:	2685211	Length:	511	Species:	Mus musculus

Alignment Length:	490	Identity:	108/490 - (22%)
Similarity:	181/490 - (36%)	Gaps:	140/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIIS 177
            |:||...||.:....|...:|..|                .:.::.|:|:|:..|..||:::...
Mouse     7 NSTQENNGSRVCLPLSKMPISVAH----------------GIIRSVVLLVILGVAFLGNVVLGYV 55

  Fly   178 VMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASIL 242
            :.|...|..:||.|:.:|.:.|::...:...:..|..:...|..:...|....||...|:.||:.
Mouse    56 LHRKPNLLQVTNRFIFNLLVTDLLQVALVAPWVVSTAIPFFWPLNIHFCTALVSLTHLFAFASVN 120

  Fly   243 HLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALLSFLPIFIGWYTTPQHQQFVIQNP 307
            .:..:|||||..|:.||.||..||.|...|:|..|||:..|.|..|:: ||    .|..|..:|
Mouse   121 TIVVVSVDRYLTIIHPLSYPSKMTNRRSYILLYGTWIAAFLQSTPPLY-GW----GHATFDDRN- 179

  Fly   308 TQCSFV--VNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQ---------------------- 348
            ..||.:  .:..|.|:|......||..:||..|..:|..|.||
Mouse   180 AFCSMIWGASPAYTVVSVVSFLVIPLGVMIACYSVVFGAARRQQALLYKAKSHRLEVRVEDSVVH 244

  Fly   349 -----------------------------------EKQLMMRHGNAMLMHRPSM---------QP 369
                                               |:..|:..|::....:.|:         :.
Mouse   245 ENEEGAKKRDEFQDKNEFQGQDGGGQAEAKGSSSMEESPMVAEGSSQKTGKGSLDFSAGIMEGKD 309

  Fly   370 SGEALSGS------------GSSKTLT-----------------------LH---EVEQEHTP-- 394
            |.|..:||            .|:|..|                       :|   :||....|
Mouse   310 SDEVSNGSMEGLEVITEFQASSAKADTGRIDANQCNIDVGEDDVEFGMDEIHFNDDVEAMRIPES 374

  Fly   395 --------TKDKHLIKMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCE-ECQVPDIVVSIL 450
                    |.|..|... .|.||||.:.:|:.|::|...|:.....|::..: :.:||..|::|:
Mouse   375 SPPSRRNSTSDPPLPPC-YECKAARVIFVIISTYVLSLGPYCFLAVLAVWVDIDTRVPQWVITII 438

  Fly   451 FWIGYFNSTLNPLIYAYFNRDFREAFRNTLLCLFC 485
            .|:.:....::|.:|.|.::..::..:..|..|.|
Mouse   439 IWLFFLQCCIHPYVYGYMHKSIKKEIQEVLKKLIC 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	54/179 (30%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	91/411 (22%)
Gpr101	NP_001028532.1	7tm_4	44..>165	CDD:304433	38/120 (32%)
		7tm_1	48..>233	CDD:278431	57/190 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..315		6/74 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..386		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910