DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and Drd2

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_036679.1	Gene:	Drd2 / 24318	RGDID:	2520	Length:	444	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	129/466 - (27%)
Similarity:	208/466 - (44%)	Gaps:	134/466 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIIS 177
            |.::||.||        .|.:|..|:.               :.|.::.|:|...:.||:||.::
  Rat    17 NWSRPFNGS--------EGKADRPHYN---------------YYAMLLTLLIFIIVFGNVLVCMA 58

  Fly   178 VMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDLWNSLDVYFSTASIL 242
            |.|.:.|:..|||.:||||:||::||.:.|.:...::|.|.|.||...||::.:|||...|||||
  Rat    59 VSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASIL 123

  Fly   243 HLCCISVDRYYAIVKPLKYPIS-MTKRVVGIMLLNTWISPALLSF---LPIFIGWYTTPQHQQFV 303
            :||.||:|||.|:..|:.|... .:||.|.:|:...|:    |||   .|:..|...|.|: :.:
  Rat   124 NLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWV----LSFTISCPLLFGLNNTDQN-ECI 183

  Fly   304 IQNPTQCSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFREANRQEKQ----------------- 351
            |.||.         :.|.||.:||::|..:.:..|:.|:....::.|:
  Rat   184 IANPA---------FVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTP 239

  Fly   352 ---------------LMMRHGNAMLMHRPSMQPSG-------EALSGSG------------SSKT 382
                           ::|:...:..::|..|..:.       |.||.:.            |...
  Rat   240 LKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQ 304

  Fly   383 LTLHEVEQE--HT-------PTKDKHL--------------------------------IKMKRE 406
            |||.:....  |:       |.|:.|.                                :..::|
  Rat   305 LTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKE 369

  Fly   407 HKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVVSILFWIGYFNSTLNPLIYAYFNRD 471
            .||.:.|.|::|.||:||||||:.:.|::.| :|.:|.::.|...|:||.||.:||:||..||.:
  Rat   370 KKATQMLAIVLGVFIICWLPFFITHILNIHC-DCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIE 433

  Fly   472 FREAFRNTLLC 482
            ||:||...|.|
  Rat   434 FRKAFMKILHC 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	67/181 (37%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	108/390 (28%)
Drd2	NP_036679.1	7tmA_D2_dopamine_R	35..438	CDD:320435	117/432 (27%)
		TM helix 1	37..61	CDD:320435	8/23 (35%)
		TM helix 2	70..92	CDD:320435	11/21 (52%)
		TM helix 3	108..130	CDD:320435	12/21 (57%)
		TM helix 4	154..170	CDD:320435	5/19 (26%)
		TM helix 5	187..210	CDD:320435	7/31 (23%)
		Interaction with PPP1R9B. /evidence=ECO:0000269\|PubMed:10391935	211..374		19/162 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..329		10/46 (22%)
		TM helix 6	373..395	CDD:320435	11/21 (52%)
		TM helix 7	406..431	CDD:320435	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910