Protein Alignment Octbeta2R and Gpr61

DIOPT Version :9

• Sequence 1: NP_001163596.2
• Gene: Octbeta2R / 41549
• FlyBaseID: FBgn0038063
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_001292390.1
• Gene: Gpr61 / 229714
• MGIID: 2441719
• Length: 449
• Species: Mus musculus
• Alignment Length: 521
• Identity: 128/521 - (24%)
• Similarity: 198/521 - (38%)
• Gaps: 127/521 - (24%)

  Fly    89 SASNSSTGGIALPLGTATPATHELNATQPFGGSGLNFNESGAGLSDHHHHQQHNPDEDWLDNIVW 153
            |:.||||.|.||    .||.        |...||:                   |:....|....
Mouse     9 SSGNSSTLGRAL----QTPG--------PSTASGV-------------------PELGLRDVASE 42

  Fly   154 VFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVA--IMAMTFNFSVQVT 216
            ....|.|||:.:.|:.||..|:..:.:...||...  ||..|.:.|::.|  :|.:....|..:.
Mouse    43 SVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFV--FVFHLCLVDLLAALTLMPLAMLSSSALF 105

  Fly   217 GRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISP 281
            ....|....|.|:..|.|.|.:.:||.:..|:|:|||.:|.|::|.:.||..:|..:|:..|:..
Mouse   106 DHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKA 170

  Fly   282 ALLSFLPIF--IGWYTTPQHQQFVIQNPTQCSF-----VVNKYYAVISSSISFWIPCTIMIFTYL 339
            ..::.:|:.  :.|     .:.....|| .||.     ...:.:.|:.:.:.|.:|..::...|.
Mouse   171 LAMASVPVLGRVYW-----EEGAPSVNP-GCSLQWSHSAYCQLFVVVFAVLYFLLPLILIFVVYC 229

  Fly   340 AIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLIKMK 404
            ::||.|    :...|:||..........|.| |:||   |..|:.......:.||
Mouse   230 SMFRVA----RVAAMQHGPLPTWMETPRQRS-ESLS---SRSTMVTSSGAHQTTP---------- 276

  Fly   405 REH------KAARTLGIIMGTFILCWLPFF---LWYTLS-MTCEECQVPDIVVSILFWIGYFNST 459
              |      |||..|..:.|.|:|||||:|   |:..|| ......||.::|.    |||||..|
Mouse   277 --HRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISAGQVENVVT----WIGYFCFT 335

  Fly   460 LNPLIYAYFNRDFREAFRNTLLCLFCNWWKDRHLPLDIDIRRSSLRYDQRAKSV----------Y 514
            .||..|...||..|.......:|.|      :..|      ...||...|..|:          .
Mouse   336 SNPFFYGCLNRQIRGELSKQFVCFF------KAAP------EEELRLPSREGSIEENFLQFLQGT 388

  Fly   515 SESYLNSTTPSHRRQSQMVDNLXYRDEALLTPIAQQQQRLAAGGSRLGGQLAAAAKDGRESKDAK 579
            ||::::...||.:|:...|.:.                       |:.||:|....:..|.:...
Mouse   389 SENWVSRPLPSPKREPPPVVDF-----------------------RIPGQIAEETSEFLEQQLTS 430

  Fly   580 D 580
            |
Mouse   431 D 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	44/186 (24%)
		7tm_1	170..465	CDD:278431	85/313 (27%)
Gpr61	NP_001292390.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		11/31 (35%)
		7tmA_GPR61_GPR62-like	44..352	CDD:320348	94/339 (28%)
		TM helix 1	44..70	CDD:320348	8/25 (32%)
		TM helix 2	75..100	CDD:320348	6/26 (23%)
		TM helix 3	115..145	CDD:320348	12/29 (41%)
		TM helix 4	157..179	CDD:320348	4/21 (19%)
		TM helix 5	205..234	CDD:320348	5/28 (18%)
		TM helix 6	280..310	CDD:320348	13/29 (45%)
		TM helix 7	320..345	CDD:320348	12/28 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910