DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and npr-20

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_495888.3	Gene:	npr-20 / 188226	WormBaseID:	WBGene00011578	Length:	410	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	92/392 - (23%)
Similarity:	160/392 - (40%)	Gaps:	87/392 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 VMLLIIIAAICGNLLVIISVMRVRKLRVITNYFVVSLAMADIMVAIMAMTFNFSVQVT----GRW 219
            :..|:.:..:.||.|.:|.:.....:|..||:|:.:||:||::|||..:..|. :.:.    |.|
Worm    36 IYCLVFVVCLSGNFLTLIVMTSHPMMRTPTNFFLSNLAIADLLVAIFCILQNM-IHIVGFDHGNW 99

  Fly   220 NFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNTWISPALL 284
            ...|.:|.|:..|.......|...|..:|:::|.|::.||.....:|.....:..:..|:...|:
Worm   100 PLGPVMCKLYLGLTNIMPCTSAGILVLVSLEKYIAVLHPLSGLKLLTPEHRWVATMIVWVISILV 164

  Fly   285 SFLPIFIGWYTTPQHQQFVIQNPTQCSFVVNKYYAV---------ISSSISF--W--IPCTIMIF 336
            :| |.|:           ..||.|        |..|         |.:|.||  |  ||.|.::|
Worm   165 NF-PYFL-----------YAQNYT--------YLGVSACFRGSMPIWNSFSFIVWYLIPLTALVF 209

  Fly   337 TYLAIFR-----EANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKT-------------L 383
            .|..|..     ::|||..             |.|.:.:|....|:|.:.|             :
Worm   210 IYSRISHLLWTSDSNRQSS-------------RQSHESNGSLERGNGYANTAQPGSSWQMKNGRI 261

  Fly   384 TLHEVEQ-EHTPTKDKHLIKMKR------EHKAARTLGIIMGTFILCWLPFF--LWYTLSMTCEE 439
            .:::.|. .:.|.::|.:.:.||      ..|..|.|..::.:|.|...|..  |.||...|...
Worm   262 VVYKQESLLNVPKREKKVKEPKRPKDTEGRRKVVRLLVAVVVSFALLTFPHHARLLYTSFQTGTI 326

  Fly   440 CQVPDIVV----SILFWIGYFNSTLNPLIYAYFNRDFREAFRNTLLC---LFCNWWKDRHLPLDI 497
            |.....::    |.:|.  :.:|.:||::||..::.||.|..:.:.|   :|....:.|:..|..
Worm   327 CNSNWTMIFQPLSYIFL--FISSAINPILYACLSKRFRNALSDVIHCRKGVFSRISRSRNRTLVS 389

  Fly   498 DI 499
            |:
Worm   390 DV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	50/194 (26%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	81/342 (24%)
npr-20	NP_495888.3	7tmA_Trissin_R	32..365	CDD:320140	86/364 (24%)
		TM helix 1	33..57	CDD:320140	5/20 (25%)
		TM helix 2	66..88	CDD:320140	9/21 (43%)
		TM helix 3	107..129	CDD:320140	4/21 (19%)
		TM helix 4	152..168	CDD:320140	3/16 (19%)
		TM helix 5	189..212	CDD:320140	9/22 (41%)
		TM helix 6	292..317	CDD:320140	6/24 (25%)
		TM helix 7	333..358	CDD:320140	7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910