DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta2R and gnrr-7

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001379083.1	Gene:	gnrr-7 / 184414	WormBaseID:	WBGene00008737	Length:	381	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	82/405 - (20%)
Similarity:	148/405 - (36%)	Gaps:	126/405 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 PDEDWLDNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLRVITNY------------FVVSL 195
            |:..|.:    |.:|.::.:..||.|....::.|.:...||::....:            |..||
Worm    13 PERLWSE----VTEASILFIYDIAYIIVGFIIAIKLYNQRKVKRPIQHNGQSGNHNSFLLFKTSL 73

  Fly   196 AMADIMVAIMAMTFNFSVQVTGRWNFSPFLCDL---WNSLDVYFSTASILHLCCISVDRYYAIVK 257
            ..:|.|:..:.........:...|.:....|.:   |:|: .:||.::|  :|.|::|||.::
Worm    74 FASDCMIMFIYAAVKALWLLQFEWKYGSLWCKMYRYWSSV-AFFSNSNI--VCGIALDRYLSV-- 133

  Fly   258 PLKYPISMTKRVVGI--------MLLNTWISPALLSFLPIFIGWYT----TPQHQQFV------- 303
                   .:..::|:        ||...||. ||::.||..|.|.|    :...:|.|
Worm   134 -------YSNHIIGVRQYQRTKRMLYAVWII-ALIAALPQLIVWETYRPSSEDWEQCVTVFAIDL 190

  Fly   304 ----IQNPTQ-----CSFVVNKYYAVISSSISFWIPCTIMIFTYLAIFR--------------EA 345
                :.:|.:     ||.:...|:    .:::||:|.:|.|.:|:.:..              |.
Worm   191 HKLPLNSPKKDEINFCSMLYEGYH----QAMAFWLPLSITIASYVRMMSRLIPFWPFTVLNHYED 251

  Fly   346 NRQE----------KQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHL 400
            .||:          .:.:.......:..|.|.        .|..|..:.|.|..: |.||.
Worm   252 ERQQTLCTIFWSKISEKIRSFFCVTIFRRKSY--------ASQQSVRVPLAETIR-HPPTT---- 303

  Fly   401 IKMKREHKAARTLG--------IIMGTFILCWLPFFLWYTLSMTCEE------CQVPDIVVSILF 451
                   ...|.||        .|:.|.|:.|||:.: .:||....|      .|....:..:|.
Worm   304 -------ALRRQLGTTVFKNACAIIVTHIILWLPYNI-ISLSRFVNEGFYETISQNGGNLFELLI 360

  Fly   452 WIGYFNSTLNPLIYA 466
            .:..|   |||::|:
Worm   361 LLSSF---LNPILYS 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	47/220 (21%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	74/375 (20%)
gnrr-7	NP_001379083.1	7tm_GPCRs	24..371	CDD:421689	77/387 (20%)
		TM helix 2	54..93	CDD:410628	5/38 (13%)
		TM helix 3	104..133	CDD:410628	11/31 (35%)
		TM helix 4	146..167	CDD:410628	8/21 (38%)
		TM helix 5	192..264	CDD:410628	13/75 (17%)
		TM helix 6	303..338	CDD:410628	10/46 (22%)
		TM helix 7	350..371	CDD:410628	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910