DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta2R and DRD1

DIOPT Version :9

Sequence 1:	NP_001163596.2	Gene:	Octbeta2R / 41549	FlyBaseID:	FBgn0038063	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_000785.1	Gene:	DRD1 / 1812	HGNCID:	3020	Length:	446	Species:	Homo sapiens

Alignment Length:	346	Identity:	124/346 - (35%)
Similarity:	193/346 - (55%)	Gaps:	29/346 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 DNIVWVFKAFVMLLIIIAAICGNLLVIISVMRVRKLR-VITNYFVVSLAMADIMVAIMAMTFNFS 212
            |..|.:..|..:.|:|::.:.||.||..:|:|.|.|| .:||:||:|||::|::||::.|.:...
Human    19 DFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAV 83

  Fly   213 VQVTGRWNFSPFLCDLWNSLDVYFSTASILHLCCISVDRYYAIVKPLKYPISMTKRVVGIMLLNT 277
            .::.|.|.|..| |::|.:.|:..||||||:||.||||||:||..|.:|...||.:...|::...
Human    84 AEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVA 147

  Fly   278 WISPALLSFLPIFIGWY----TTPQ--HQQFVIQNPTQCSFVVNKYYAVISSSISFWIPCTIMIF 336
            |....|:||:|:.:.|:    |:|.  :...:.:....|...:::.||:.||.|||:||..|||.
Human   148 WTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIV 212

  Fly   337 TYLAIFREANRQEKQLMMRHGNAMLMHRPSMQPSGEALSGSGSSKTLTLHEVEQEHTPTKDKHLI 401
            ||..|:|.|.:|.:::......|  :|..:.|.:      :|:.|.:   |..|..:..|    :
Human   213 TYTRIYRIAQKQIRRIAALERAA--VHAKNCQTT------TGNGKPV---ECSQPESSFK----M 262

  Fly   402 KMKREHKAARTLGIIMGTFILCWLPFFLWYTLSMTCEECQVPDIVV-----SILFWIGYFNSTLN 461
            ..|||.|..:||.:|||.|:.||||||:...:...|...:.....:     .:..|.|:.||:||
Human   263 SFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLN 327

  Fly   462 PLIYAYFNRDFREAFRNTLLC 482
            |:||| ||.|||:||...|.|
Human   328 PIIYA-FNADFRKAFSTLLGC 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta2R	NP_001163596.2	7tm_4	164..>342	CDD:304433	72/184 (39%)
Octbeta2R	NP_001163596.2	7tm_1	170..465	CDD:278431	107/306 (35%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	118/334 (35%)
		TM helix 1	26..50	CDD:320443	8/23 (35%)
		TM helix 2	60..82	CDD:320443	10/21 (48%)
		TM helix 3	97..119	CDD:320443	11/21 (52%)
		TM helix 4	142..158	CDD:320443	5/15 (33%)
		TM helix 5	192..215	CDD:320443	13/22 (59%)
		TM helix 6	271..293	CDD:320443	12/21 (57%)
		TM helix 7	310..335	CDD:320443	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.970